Literature DB >> 26811741

Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.

Jonathan R Chekan1, Dillon P Cogan1, Satish K Nair2.   

Abstract

Research in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review the current state of knowledge of the structural and biochemical characterization of resistance mechanisms against these bioactive natural products. Advances in the understanding of these resistance determinants have spurred knowledge-based campaigns aimed towards the design of derivatives that retain biological activity but are less prone to tolerance.

Entities:  

Year:  2015        PMID： 26811741      PMCID： PMC4723106          DOI： 10.1039/C5MD00351B

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  63 in total

1.  Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.

Authors:  Sarah Ponaire; Catherine Zinglé; Denis Tritsch; Catherine Grosdemange-Billiard; Michel Rohmer
Journal:  Eur J Med Chem       Date:  2012-02-25       Impact factor: 6.514

2.  Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli.

Authors:  Yafei Huang; M Joanne Lemieux; Jinmei Song; Manfred Auer; Da-Neng Wang
Journal:  Science       Date:  2003-08-01       Impact factor: 47.728

3.  Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR).

Authors:  Catherine Zinglé; Lionel Kuntz; Denis Tritsch; Catherine Grosdemange-Billiard; Michel Rohmer
Journal:  Bioorg Med Chem Lett       Date:  2012-09-15       Impact factor: 2.823

4.  Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family.

Authors:  Ekaterina Kuznetsova; Michael Proudfoot; Claudio F Gonzalez; Greg Brown; Marina V Omelchenko; Ivan Borozan; Liran Carmel; Yuri I Wolf; Hirotada Mori; Alexei V Savchenko; Cheryl H Arrowsmith; Eugene V Koonin; Aled M Edwards; Alexander F Yakunin
Journal:  J Biol Chem       Date:  2006-09-21       Impact factor: 5.157

Review 5.  The shikimate pathway and aromatic amino Acid biosynthesis in plants.

Authors:  Hiroshi Maeda; Natalia Dudareva
Journal:  Annu Rev Plant Biol       Date:  2012       Impact factor: 26.379

6.  The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.

Authors:  Aengus Mac Sweeney; Roland Lange; Roberta P M Fernandes; Henk Schulz; Glenn E Dale; Alice Douangamath; Philip J Proteau; Christian Oefner
Journal:  J Mol Biol       Date:  2005-01-07       Impact factor: 5.469

Review 7.  Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens.

Authors:  Drosos E Karageorgopoulos; Rui Wang; Xu-Hong Yu; Matthew E Falagas
Journal:  J Antimicrob Chemother       Date:  2011-11-16       Impact factor: 5.790

8.  In vitro and in vivo antibacterial activities of FR-31564, a new phosphonic acid antibiotic.

Authors:  Y Mine; T Kamimura; S Nonoyama; M Nishida; S Goto; S Kuwahara
Journal:  J Antibiot (Tokyo)       Date:  1980-01       Impact factor: 2.649

Review 9.  Phenylpropanoid biosynthesis.

Authors:  Thomas Vogt
Journal:  Mol Plant       Date:  2009-12-24       Impact factor: 13.164

10.  Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.

Authors:  Amanda C Brown; Tanya Parish
Journal:  BMC Microbiol       Date:  2008-05-20       Impact factor: 3.605
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  3 in total

1.  Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

Authors:  Philip Olivares; Emily C Ulrich; Jonathan R Chekan; Wilfred A van der Donk; Satish K Nair
Journal:  ACS Chem Biol       Date:  2016-12-27       Impact factor: 5.100

2.  Potent, specific MEPicides for treatment of zoonotic staphylococci.

Authors:  Rachel L Edwards; Isabel Heueck; Soon Goo Lee; Ishaan T Shah; Justin J Miller; Andrew J Jezewski; Marwa O Mikati; Xu Wang; Robert C Brothers; Kenneth M Heidel; Damon M Osbourn; Carey-Ann D Burnham; Sophie Alvarez; Stephanie A Fritz; Cynthia S Dowd; Joseph M Jez; Audrey R Odom John
Journal:  PLoS Pathog       Date:  2020-06-04       Impact factor: 6.823

Review 3.  Production of β-Lactamase Inhibitors by Streptomyces Species.

Authors:  Daniela de Araújo Viana Marques; Suellen Emilliany Feitosa Machado; Valéria Carvalho Santos Ebinuma; Carolina de Albuquerque Lima Duarte; Attilio Converti; Ana Lúcia Figueiredo Porto
Journal:  Antibiotics (Basel)       Date:  2018-07-17
  3 in total

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