Literature DB >> 26811479

Nicastrin guards Alzheimer's gate.

Siniša Urban1.   

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Year:  2016        PMID： 26811479      PMCID： PMC4747721          DOI： 10.1073/pnas.1524151113

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  15 in total

Review 1.  Mechanistic insights into Notch receptor signaling from structural and biochemical studies.

Authors:  Rhett A Kovall; Stephen C Blacklow
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

2.  Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Authors:  David M Bolduc; Daniel R Montagna; Yongli Gu; Dennis J Selkoe; Michael S Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-22       Impact factor: 11.205

3.  Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.

Authors:  Frits Kamp; Edith Winkler; Johannes Trambauer; Amelie Ebke; Regina Fluhrer; Harald Steiner
Journal:  Biophys J       Date:  2015-03-10       Impact factor: 4.033

4.  Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH.

Authors:  Shangyu Dang; Shenjie Wu; Jiawei Wang; Hongbo Li; Min Huang; Wei He; Yue-Ming Li; Catherine C L Wong; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-02       Impact factor: 11.205

Review 5.  Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

Authors:  Bart De Strooper; Lucía Chávez Gutiérrez
Journal:  Annu Rev Pharmacol Toxicol       Date:  2014-10-01       Impact factor: 13.820

6.  Nuclear access and action of notch in vivo.

Authors:  G Struhl; A Adachi
Journal:  Cell       Date:  1998-05-15       Impact factor: 41.582

7.  A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

Authors:  B De Strooper; W Annaert; P Cupers; P Saftig; K Craessaerts; J S Mumm; E H Schroeter; V Schrijvers; M S Wolfe; W J Ray; A Goate; R Kopan
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

8.  Nicastrin functions as a gamma-secretase-substrate receptor.

Authors:  Sanjiv Shah; Sheu-Fen Lee; Katsuhiko Tabuchi; Yi-Heng Hao; Cong Yu; Quincey LaPlant; Haydn Ball; Charles E Dann; Thomas Südhof; Gang Yu
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

9.  Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity.

Authors:  Seth W Dickey; Rosanna P Baker; Sangwoo Cho; Siniša Urban
Journal:  Cell       Date:  2013-12-05       Impact factor: 41.582

10.  An atomic structure of human γ-secretase.

Authors:  Xiao-Chen Bai; Chuangye Yan; Guanghui Yang; Peilong Lu; Dan Ma; Linfeng Sun; Rui Zhou; Sjors H W Scheres; Yigong Shi
Journal:  Nature       Date:  2015-08-17       Impact factor: 49.962
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  1 in total

1.  Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1.

Authors:  Budheswar Dehury; Ning Tang; Tom L Blundell; Kasper P Kepp
Journal:  RSC Adv       Date:  2019-07-04       Impact factor: 4.036
  1 in total

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