Dominik Dziewiecki1, Sander van de Loo2, Felix Gremse3, Anita Kloss-Brandstätter4, Frank Kloss5, Vincent Offermanns5, Kensuke Yamauchi6, Peter Kessler7, Bernd Lethaus8. 1. Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. 2. Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center, P.O. Box 7057, 1007MB Amsterdam, The Netherlands. 3. Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. 4. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria. 5. Department for Cranio-Maxillofacial and Oral Surgery, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria. 6. Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, 980-8575 Sendai, Miyagi, Japan. 7. Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, P. Debbyelaan, 6202 AZ Maastricht, The Netherlands. 8. Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: blethaus@ukaachen.de.
Abstract
INTRODUCTION: Periosteal distraction or elevation has been known as an experimental method to induce new bone formation. Although it uses the principles of distraction osteogenesis no further osteotomy is necessary. The purpose of this study was to test devices of different materials and to evaluate the point of origin of the new bone formation. MATERIAL & METHODS: On each calvaria of twelve male adult Göttingen Minipigs three devices were implanted. The materials used were degradable PDLLA (poly-DL-lactide), PGA (polyglycolic acid) and nondegradable Ti (titanium). After a consolidation time of 2, 4 and 6 weeks days a total of 36 specimens were harvested. To identify the total amount of newly created bone, micro-CT and histological analysis were performed. RESULTS: All degradable devices collapsed to a certain extent within the observation time but osteoneogenesis took place in all materials after a consolidation time of 2, 4 and 6 weeks after implantation above and under the devices. No statistical significant differences between the materials were found. However, most bone formation took place in the space under the periosteum and above the devices (p < 0.001). CONCLUSION: Periosteal elevation can produce new bone formation with degradable devices, which derives from the periosteum and the underlying bone. In this interaction the periosteum seems to contain the larger share.
INTRODUCTION: Periosteal distraction or elevation has been known as an experimental method to induce new bone formation. Although it uses the principles of distraction osteogenesis no further osteotomy is necessary. The purpose of this study was to test devices of different materials and to evaluate the point of origin of the new bone formation. MATERIAL & METHODS: On each calvaria of twelve male adult Göttingen Minipigs three devices were implanted. The materials used were degradable PDLLA (poly-DL-lactide), PGA (polyglycolic acid) and nondegradable Ti (titanium). After a consolidation time of 2, 4 and 6 weeks days a total of 36 specimens were harvested. To identify the total amount of newly created bone, micro-CT and histological analysis were performed. RESULTS: All degradable devices collapsed to a certain extent within the observation time but osteoneogenesis took place in all materials after a consolidation time of 2, 4 and 6 weeks after implantation above and under the devices. No statistical significant differences between the materials were found. However, most bone formation took place in the space under the periosteum and above the devices (p < 0.001). CONCLUSION: Periosteal elevation can produce new bone formation with degradable devices, which derives from the periosteum and the underlying bone. In this interaction the periosteum seems to contain the larger share.