Literature DB >> 26810783

An Overview of Genome-Wide Association Studies in Alzheimer's Disease.

Luxi Shen1, Jianping Jia2,3,4,5.   

Abstract

Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.

Entities:  

Keywords:  Alzheimer’s disease susceptibility genes; Apolipoprotein E; Association analysis; Common variant

Mesh：

Substances：

Year:  2016        PMID： 26810783      PMCID： PMC5563735          DOI： 10.1007/s12264-016-0011-3

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  72 in total

1.  The very high prevalence of AD in an Arab population is not explained by APOE epsilon4 allele frequency.

Authors:  A Bowirrat; R P Friedland; J Chapman; A D Korczyn
Journal:  Neurology       Date:  2000-09-12       Impact factor: 9.910

2.  Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data.

Authors:  Richard Sherva; Clinton T Baldwin; Rivka Inzelberg; Badri Vardarajan; L Adrienne Cupples; Kathryn Lunetta; Abdalla Bowirrat; Adam Naj; Margaret Pericak-Vance; Robert P Friedland; Lindsay A Farrer
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

3.  Genetic susceptibility for Alzheimer disease neuritic plaque pathology.

Authors:  Joshua M Shulman; Kewei Chen; Brendan T Keenan; Lori B Chibnik; Adam Fleisher; Pradeep Thiyyagura; Auttawut Roontiva; Cristin McCabe; Nikolaos A Patsopoulos; Jason J Corneveaux; Lei Yu; Matthew J Huentelman; Denis A Evans; Julie A Schneider; Eric M Reiman; Philip L De Jager; David A Bennett
Journal:  JAMA Neurol       Date:  2013-09-01       Impact factor: 18.302

Review 4.  Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.

Authors:  Richard Sherva; Lindsay A Farrer
Journal:  Curr Psychiatry Rep       Date:  2011-04       Impact factor: 5.285

5.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

6.  Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.

Authors:  Minerva M Carrasquillo; Fanggeng Zou; V Shane Pankratz; Samantha L Wilcox; Li Ma; Louise P Walker; Samuel G Younkin; Curtis S Younkin; Linda H Younkin; Gina D Bisceglio; Nilufer Ertekin-Taner; Julia E Crook; Dennis W Dickson; Ronald C Petersen; Neill R Graff-Radford; Steven G Younkin
Journal:  Nat Genet       Date:  2009-01-11       Impact factor: 38.330

7.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Authors:  W J Strittmatter; A M Saunders; D Schmechel; M Pericak-Vance; J Enghild; G S Salvesen; A D Roses
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

8.  Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.

Authors:  Andrew Grupe; Richard Abraham; Yonghong Li; Charles Rowland; Paul Hollingworth; Angharad Morgan; Luke Jehu; Ricardo Segurado; David Stone; Eric Schadt; Maha Karnoub; Petra Nowotny; Kristina Tacey; Joseph Catanese; John Sninsky; Carol Brayne; David Rubinsztein; Michael Gill; Brian Lawlor; Simon Lovestone; Peter Holmans; Michael O'Donovan; John C Morris; Leon Thal; Alison Goate; Michael J Owen; Julie Williams
Journal:  Hum Mol Genet       Date:  2007-02-22       Impact factor: 6.150

9.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330

10.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Authors:  R Sherrington; E I Rogaev; Y Liang; E A Rogaeva; G Levesque; M Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; S Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; R E Tanzi; A D Roses; P E Fraser; J M Rommens; P H St George-Hyslop
Journal:  Nature       Date:  1995-06-29       Impact factor: 49.962
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  26 in total

Review 1.  Missing heritability of complex diseases: case solved?

Authors:  Emmanuelle Génin
Journal:  Hum Genet       Date:  2019-06-04       Impact factor: 4.132

Review 2.  The Mitochondrion: A Potential Therapeutic Target for Alzheimer's Disease.

Authors:  Mei-Hong Lu; Xiu-Yun Zhao; Pei-Pei Yao; De-En Xu; Quan-Hong Ma
Journal:  Neurosci Bull       Date:  2018-11-12       Impact factor: 5.203

3.  The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor.

Authors:  Ali Sazci; Nihal Uren; Halil Atilla Idrisoglu; Emel Ergul
Journal:  Neurosci Bull       Date:  2018-09-17       Impact factor: 5.203

4.  Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer's disease.

Authors:  Caterina Branca; Eric Ferreira; Thuy-Vi Nguyen; Kristian Doyle; Antonella Caccamo; Salvatore Oddo
Journal:  Hum Mol Genet       Date:  2017-12-15       Impact factor: 6.150

Review 5.  Membrane Aging as the Real Culprit of Alzheimer's Disease: Modification of a Hypothesis.

Authors:  Qiujian Yu; Chunjiu Zhong
Journal:  Neurosci Bull       Date:  2017-11-24       Impact factor: 5.203

6.  Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.

Authors:  Jessica S Sadick; Lorin A Crawford; Harry C Cramer; Christian Franck; Shane A Liddelow; Eric M Darling
Journal:  Ann Biomed Eng       Date:  2020-04-17       Impact factor: 3.934

7.  Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer's disease?

Authors:  Tamas Fulop; Jacek M Witkowski; Anis Larbi; Abdelouahed Khalil; Georges Herbein; Eric H Frost
Journal:  J Neurovirol       Date:  2019-03-13       Impact factor: 2.643

Review 8.  Autophagy Balances Neuroinflammation in Alzheimer's Disease.

Authors:  Xuehua Cheng; Yong Wei; Zijun Qian; Li Han
Journal:  Cell Mol Neurobiol       Date:  2022-08-12       Impact factor: 4.231

9.  Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans.

Authors:  Aziz M Mezlini; Colin Magdamo; Emily Merrill; Lori B Chibnik; Deborah L Blacker; Bradley T Hyman; Sudeshna Das
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

Review 10.  A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy.

Authors:  Kundlik Gadhave; Deepak Kumar; Vladimir N Uversky; Rajanish Giri
Journal:  Med Res Rev       Date:  2020-08-11       Impact factor: 12.388
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