Hideki Kanemoto1, Hiroaki Kazui2, Yukiko Suzuki1, Syunsuke Sato1, Haruhiko Kishima3, Toshiki Yoshimine3, Kenji Yoshiyama1. 1. Department of Psychiatry, Osaka University Graduate School of Medicine, D3 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan. 2. Department of Psychiatry, Osaka University Graduate School of Medicine, D3 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan. Electronic address: kazui@psy.med.osaka-u.ac.jp. 3. Neurosurgery, Osaka University Graduate School of Medicine, D3 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan.
Abstract
INTRODUCTION: Patients with idiopathic normal pressure hydrocephalus (iNPH) have neuropsychiatric symptoms that could affect patients' quality of life and caregiver burden. In this study, we assessed the effect of lumbo-peritoneal (L-P) shunt surgery on neuropsychiatric symptoms and the association between neuropsychiatric symptoms and caregiver burden after L-P shunt surgery. METHODS: We recruited 22 iNPH patients who had L-P shunt surgery and who were followed up for 3 months after surgery. Neuropsychiatric symptoms and caregiver burden were evaluated with the Neuropsychiatric Inventory (NPI) and Zarit Burden Interview (ZBI), respectively, before and 3 months after surgery. We evaluated the changes of NPI and ZBI and the association between the changes in these 2 scores and the triad symptoms. RESULTS: NPI total, apathy, and depression scores significantly decreased after surgery. The improvement in NPI total, apathy, disinhibition, and irritability scores after surgery were significantly and positively associated with improvement in ZBI score after surgery. Improvement in NPI apathy score was significantly associated with improvement in Frontal Assessment Battery score after surgery. CONCLUSION: L-P shunt surgery was effective in reducing not only the triad symptoms but also the neuropsychiatric symptoms, and the improved neuropsychiatric symptoms might decrease caregiver burden for iNPH patients.
INTRODUCTION:Patients with idiopathic normal pressure hydrocephalus (iNPH) have neuropsychiatric symptoms that could affect patients' quality of life and caregiver burden. In this study, we assessed the effect of lumbo-peritoneal (L-P) shunt surgery on neuropsychiatric symptoms and the association between neuropsychiatric symptoms and caregiver burden after L-P shunt surgery. METHODS: We recruited 22 iNPH patients who had L-P shunt surgery and who were followed up for 3 months after surgery. Neuropsychiatric symptoms and caregiver burden were evaluated with the Neuropsychiatric Inventory (NPI) and Zarit Burden Interview (ZBI), respectively, before and 3 months after surgery. We evaluated the changes of NPI and ZBI and the association between the changes in these 2 scores and the triad symptoms. RESULTS: NPI total, apathy, and depression scores significantly decreased after surgery. The improvement in NPI total, apathy, disinhibition, and irritability scores after surgery were significantly and positively associated with improvement in ZBI score after surgery. Improvement in NPI apathy score was significantly associated with improvement in Frontal Assessment Battery score after surgery. CONCLUSION: L-P shunt surgery was effective in reducing not only the triad symptoms but also the neuropsychiatric symptoms, and the improved neuropsychiatric symptoms might decrease caregiver burden for iNPH patients.
Authors: Madison Niermeyer; Chad Gaudet; Paul Malloy; Irene Piryatinsky; Stephen Salloway; Petra Klinge; Athene Lee Journal: J Int Neuropsychol Soc Date: 2020-05-20 Impact factor: 2.892
Authors: Katie A Peterson; Tom B Mole; Nicole C H Keong; Elise E DeVito; George Savulich; John D Pickard; Barbara J Sahakian Journal: Acta Neurol Scand Date: 2018-12-03 Impact factor: 3.209