Sara Tylner1, Tommy Cederholm2, Gerd Faxén-Irving3. 1. Huddinge Municipality, Huddinge, Sweden. 2. Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden. 3. Clinical Geriatrics, Neurobiology Care Sciences and Society, Karolinska Institute and Department of Clinical Nutrition and Dietetics, Karolinska University Hospital, Stockholm, Sweden. Electronic address: gerd.faxen.irving@ki.se.
Abstract
OBJECTIVES: Dietary intake in frail old adults is often lower than estimated needs. The aim of this study was to evaluate the effects of an energy-dense oral supplement on nutritional status, food intake, and physical function in residents living in care residential homes. DESIGN: Randomized controlled intervention trial with a crossover design. SETTING: Five care residential homes in the southern Stockholm area. PARTICIPANTS: Older people living at care residential homes: age 65 or older, malnourished or at risk of malnutrition according to Mini Nutritional Assessment-Short Form (MNA-SF). INTERVENTION: Energy-dense formula (oleic and linoleic acid emulsion enriched with protein and micronutrients) (Calogen Extra, Nutricia) 30 mL distributed 3 times daily for 6 weeks. MEASUREMENTS: Body weight, 3-day food and fluid record, appetite rating, and physical function (ie, Short Physical Performance Battery, grip strength, and peak expiratory flow). Biochemical indicators of nutritional status, blood lipids, and serum phospholipid fatty acid (FA) profile. RESULTS:Twenty-eight participants completed the 2 phases of the crossover study; group A (n = 14, 87 ± 6 years, 50% women) and group B (n = 14, 82 ± 8 years, 71% women). The intervention periods combined resulted in significantly (P < .05) increased energy intake (238 ± 544 kcal), weight gain (1.4 ± 3.7 kg), improved appetite, relative reduction of saturated FA and increase in polyunsaturated FA, increased apoliporotein A, and reduced serum fibrinogen (-0.9 ± 1.5 g/L). CONCLUSION: Distribution of an oleic and linoleic acid based fat emulsion enriched with protein and micronutrients (Calogen Extra) 3 times daily to old people in care residential homes improved nutritional status, had positive effects on fatty acid profile and blood lipids, and a potential antithrombotic effect. CLINICALTRIALS. GOV IDENTIFIER: NCT01259999.
RCT Entities:
OBJECTIVES: Dietary intake in frail old adults is often lower than estimated needs. The aim of this study was to evaluate the effects of an energy-dense oral supplement on nutritional status, food intake, and physical function in residents living in care residential homes. DESIGN: Randomized controlled intervention trial with a crossover design. SETTING: Five care residential homes in the southern Stockholm area. PARTICIPANTS: Older people living at care residential homes: age 65 or older, malnourished or at risk of malnutrition according to Mini Nutritional Assessment-Short Form (MNA-SF). INTERVENTION: Energy-dense formula (oleic and linoleic acid emulsion enriched with protein and micronutrients) (Calogen Extra, Nutricia) 30 mL distributed 3 times daily for 6 weeks. MEASUREMENTS: Body weight, 3-day food and fluid record, appetite rating, and physical function (ie, Short Physical Performance Battery, grip strength, and peak expiratory flow). Biochemical indicators of nutritional status, blood lipids, and serum phospholipid fatty acid (FA) profile. RESULTS: Twenty-eight participants completed the 2 phases of the crossover study; group A (n = 14, 87 ± 6 years, 50% women) and group B (n = 14, 82 ± 8 years, 71% women). The intervention periods combined resulted in significantly (P < .05) increased energy intake (238 ± 544 kcal), weight gain (1.4 ± 3.7 kg), improved appetite, relative reduction of saturated FA and increase in polyunsaturated FA, increased apoliporotein A, and reduced serum fibrinogen (-0.9 ± 1.5 g/L). CONCLUSION: Distribution of an oleic and linoleic acid based fat emulsion enriched with protein and micronutrients (Calogen Extra) 3 times daily to old people in care residential homes improved nutritional status, had positive effects on fatty acid profile and blood lipids, and a potential antithrombotic effect. CLINICALTRIALS. GOV IDENTIFIER: NCT01259999.
Authors: Minkyung Kim; Minjoo Kim; Ayoung Lee; Hye Jin Yoo; Jung Soo Her; Sun Ha Jee; Jong Ho Lee Journal: Nutr Metab (Lond) Date: 2017-05-08 Impact factor: 4.169