Literature DB >> 26810366

Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives.

Yuliya V Tarasenko1, Tatyana V Abramova1, Viktor I Mamatuk2, Vladimir N Silnikov1,3.   

Abstract

Morpholino nucleoside triphosphates (A, U, G, C, T) bearing the active functional amino group tethered to morpholine residue and their fluorescently labeled derivatives were synthesized. All compounds were characterized by (1)H, (13)C, and (31)P NMR, and mass spectrometry. A possibility of using fluorescently labeled morpholino nucleoside triphosphates as chain terminators in DNA sequencing is discussed.

Entities:  

Keywords:  Morpholino nucleosides; fluorescent labeling; triphosphates

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Substances：

Year:  2016        PMID： 26810366     DOI： 10.1080/15257770.2015.1114125

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  3 in total

1.  A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors.

Authors:  Yuliya V Sherstyuk; Alexandra L Zakharenko; Mikhail M Kutuzov; Polina V Chalova; Maria V Sukhanova; Olga I Lavrik; Vladimir N Silnikov; Tatyana V Abramova
Journal:  Mol Divers       Date:  2016-09-27       Impact factor: 2.943

2.  Nucleobase morpholino β amino acids as molecular chimeras for the preparation of photoluminescent materials from ribonucleosides.

Authors:  Raffaella Bucci; Alberto Bossi; Emanuela Erba; Francesco Vaghi; Abhijit Saha; Sivan Yuran; Daniela Maggioni; Maria Luisa Gelmi; Meital Reches; Sara Pellegrino
Journal:  Sci Rep       Date:  2020-11-09       Impact factor: 4.379

3.  Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3.

Authors:  Yuliya V Sherstyuk; Nikita V Ivanisenko; Alexandra L Zakharenko; Maria V Sukhanova; Roman Y Peshkov; Ilia V Eltsov; Mikhail M Kutuzov; Tatjana A Kurgina; Ekaterina A Belousova; Vladimir A Ivanisenko; Olga I Lavrik; Vladimir N Silnikov; Tatyana V Abramova
Journal:  Int J Mol Sci       Date:  2019-12-27       Impact factor: 5.923
  3 in total

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