Maryam Abbasian1, Hossein Ebrahimi2, Mehrei Delvarianzadeh3, Pirasteh Norouzi4, Mozhgan Fazli5. 1. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Electronic address: abbasian@shmu.ac.ir. 2. Center for Health-Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Electronic address: h_ebrahimi43@yahoo.com. 3. School of public Health, Shahroud University of Medical Sciences, Shahroud, Iran. Electronic address: delvarianadeh_mehri@yahoo.com. 4. Department of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Electronic address: pirasteh_norozi@yahoo.com. 5. Department of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Electronic address: fazlimozhgan@yahoo.com.
Abstract
AIMS: Serum uric acid level has been suggested to be associated with metabolic syndrome risk factors. However, the association between metabolic syndrome and serum uric acid is still controversial and challenging. This study was aimed to investigate the association between serum uric acid levels and metabolic syndrome components in personnel of the Shahroud University of Medical Sciences. MATERIAL AND METHODS: This case-control study was conducted on 499 personnel aged 30-60 years old who were working in Shahroud University of Medical Sciences, in 2015. MetS was defined according to the National Cholesterol Education Program (NCEP) criteria. The relationship between serum UA level and the number of metabolic components was determined by linear regression analysis. RESULT: In this study, the mean concentration of serum uric acid in men with the syndrome was higher than that in women. Mean serum UA level increased as the number of metabolic factors increased. The mean serum uric acid levels was 4.98±1.64 in patients with metabolic syndrome and 4.5±1.28 in non-patients (p=0.005). Subject with abnormal uric acid were almost 2.62 times more likely than other subject to develop the syndrome. CONCLUSIONS: The results of this study showed that only hypertriglyceridemia is a component which increases the risk of hyperuricemia. In addition, hyperuricemia increases the risk of metabolic syndrome by more than two fold. It seems that high uric acid can be considered as a predisposing factor for metabolic syndrome; thus, it is recommended to measure serum uric acid in routine tests.
AIMS: Serum uric acid level has been suggested to be associated with metabolic syndrome risk factors. However, the association between metabolic syndrome and serum uric acid is still controversial and challenging. This study was aimed to investigate the association between serum uric acid levels and metabolic syndrome components in personnel of the Shahroud University of Medical Sciences. MATERIAL AND METHODS: This case-control study was conducted on 499 personnel aged 30-60 years old who were working in Shahroud University of Medical Sciences, in 2015. MetS was defined according to the National Cholesterol Education Program (NCEP) criteria. The relationship between serum UA level and the number of metabolic components was determined by linear regression analysis. RESULT: In this study, the mean concentration of serum uric acid in men with the syndrome was higher than that in women. Mean serum UA level increased as the number of metabolic factors increased. The mean serum uric acid levels was 4.98±1.64 in patients with metabolic syndrome and 4.5±1.28 in non-patients (p=0.005). Subject with abnormal uric acid were almost 2.62 times more likely than other subject to develop the syndrome. CONCLUSIONS: The results of this study showed that only hypertriglyceridemia is a component which increases the risk of hyperuricemia. In addition, hyperuricemia increases the risk of metabolic syndrome by more than two fold. It seems that high uric acid can be considered as a predisposing factor for metabolic syndrome; thus, it is recommended to measure serum uric acid in routine tests.
Authors: Khadijeh Kalan Farmanfarma; Mahmoud Ali Kaykhaei; Mehdi Mohammadi; Hussein Ali Adineh; Alireza Ansari-Moghaddam Journal: J Med Life Date: 2020 Oct-Dec