Literature DB >> 26809802

A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift.

Hyeun Bum Kim1,2, Yuankai Wang1,3, Xingmin Sun4.   

Abstract

We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.

Entities:  

Keywords:  Antibiotics; Clostridium difficile infection; Gut; Immunosuppressive drug; Microbiota

Mesh：

Substances：

Year:  2016        PMID： 26809802      PMCID： PMC4832933          DOI： 10.4014/jmb.1512.12017

Source DB:  PubMed          Journal:  J Microbiol Biotechnol        ISSN： 1017-7825            Impact factor:   2.351


  26 in total

1.  Integration of microbial ecology and statistics: a test to compare gene libraries.

Authors:  Patrick D Schloss; Bret R Larget; Jo Handelsman
Journal:  Appl Environ Microbiol       Date:  2004-09       Impact factor: 4.792

2.  Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge.

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Journal:  J Clin Microbiol       Date:  2005-11       Impact factor: 5.948

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Journal:  Trends Microbiol       Date:  1996-11       Impact factor: 17.079

4.  Mouse relapse model of Clostridium difficile infection.

Authors:  Xingmin Sun; Haiying Wang; Yongrong Zhang; Kevin Chen; Barbara Davis; Hanping Feng
Journal:  Infect Immun       Date:  2011-05-16       Impact factor: 3.441

5.  Risk of infectious complications in patients taking glucocorticosteroids.

Authors:  A E Stuck; C E Minder; F J Frey
Journal:  Rev Infect Dis       Date:  1989 Nov-Dec

6.  Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin.

Authors:  Hyeun Bum Kim; Klaudyna Borewicz; Bryan A White; Randall S Singer; Srinand Sreevatsan; Zheng Jin Tu; Richard E Isaacson
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-06       Impact factor: 11.205

7.  Piglet models of acute or chronic Clostridium difficile illness.

Authors:  Jennifer Steele; Hanping Feng; Nicola Parry; Saul Tzipori
Journal:  J Infect Dis       Date:  2010-02-01       Impact factor: 5.226

8.  A pig model of the human gastrointestinal tract.

Authors:  Quanshun Zhang; Giovanni Widmer; Saul Tzipori
Journal:  Gut Microbes       Date:  2013-04-02

9.  UCHIME improves sensitivity and speed of chimera detection.

Authors:  Robert C Edgar; Brian J Haas; Jose C Clemente; Christopher Quince; Rob Knight
Journal:  Bioinformatics       Date:  2011-06-23       Impact factor: 6.937

10.  Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota.

Authors:  Eliette Riboulet-Bisson; Mark H J Sturme; Ian B Jeffery; Michelle M O'Donnell; B Anne Neville; Brian M Forde; Marcus J Claesson; Hugh Harris; Gillian E Gardiner; Patrick G Casey; Peadar G Lawlor; Paul W O'Toole; R Paul Ross
Journal:  PLoS One       Date:  2012-02-17       Impact factor: 3.240
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  6 in total

1.  Impact of superimposed Clostridium difficile infection in Crohn's or ulcerative colitis flares in the outpatient setting.

Authors:  Patrícia Guedes Garcia; Liliana Andrade Chebli; Tarsila Campanha da Rocha Ribeiro; Pedro Duarte Gaburri; Fabio Heleno de Lima Pace; Kátia Valéria Bastos Dias Barbosa; Lívia Almeida Costa; William de Almeida Cruz; Isabelle Carvalho de Assis; Bernardo Rodriguez Mendes Moraes; Alexandre Zanini; Julio Maria Fonseca Chebli
Journal:  Int J Colorectal Dis       Date:  2018-06-21       Impact factor: 2.571

2.  Association Between Immunosuppressive Therapy and Outcome of Clostridioides difficile Infection: Systematic Review and Meta-Analysis.

Authors:  Yiting Li; Haifeng Cai; Daniel A Sussman; Jean Donet; Kevin Dholaria; Jiajia Yang; Ami Panara; Ryan Croteau; Jamie S Barkin
Journal:  Dig Dis Sci       Date:  2021-09-23       Impact factor: 3.487

3.  Blueberry Phenolics Reduce Gastrointestinal Infection of Patients with Cerebral Venous Thrombosis by Improving Depressant-Induced Autoimmune Disorder via miR-155-Mediated Brain-Derived Neurotrophic Factor.

Authors:  Ning Xu; Hao Meng; Tianyi Liu; Yingli Feng; Yuan Qi; Donghuan Zhang; Honglei Wang
Journal:  Front Pharmacol       Date:  2017-11-27       Impact factor: 5.810

4.  Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in a Pediatric Heart Transplant Patient.

Authors:  Kyle L Flannigan; Taylor Rajbar; Andrew Moffat; Leanna S McKenzie; Frank Dicke; Kevin Rioux; Matthew L Workentine; Thomas J Louie; Simon A Hirota; Steven C Greenway
Journal:  Front Cardiovasc Med       Date:  2017-04-04

5.  Molecular, microbiological and clinical characterization of Clostridium difficile isolates from tertiary care hospitals in Colombia.

Authors:  Clara Lina Salazar; Catalina Reyes; Santiago Atehortua; Patricia Sierra; Margarita María Correa; Daniel Paredes-Sabja; Emma Best; Warren N Fawley; Mark Wilcox; Ángel González
Journal:  PLoS One       Date:  2017-09-13       Impact factor: 3.240

Review 6.  Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection.

Authors:  Duolong Zhu; Joseph A Sorg; Xingmin Sun
Journal:  Front Cell Infect Microbiol       Date:  2018-02-08       Impact factor: 5.293
  6 in total

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