Otília Lupi1, Felipe Ridolfi2, Sidnei da Silva3, Graziela Maria Zanini3, Aline Lavigne4, Rita Maria Ribeiro Nogueira5, Maria de Fátima Ferreira da Cruz4, Cláudio Tadeu Daniel-Ribeiro4, Patrícia Brasil6. 1. Laboratório de Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, CEP 21.040-900, Manguinhos, Rio de Janeiro, RJ, Brazil; Centro de Pesquisa, Diagnóstico e Treinamento em Malária, FIOCRUZ, Rio de Janeiro, RJ, Brazil. Electronic address: otilia.lupi@ini.fiocruz.br. 2. Laboratório de Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, CEP 21.040-900, Manguinhos, Rio de Janeiro, RJ, Brazil. 3. Centro de Pesquisa, Diagnóstico e Treinamento em Malária, FIOCRUZ, Rio de Janeiro, RJ, Brazil; Laboratório de Parasitologia, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brazil. 4. Centro de Pesquisa, Diagnóstico e Treinamento em Malária, FIOCRUZ, Rio de Janeiro, RJ, Brazil; Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Leônidas Deane, RJ, Brazil. 5. Laboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Helio Pereira, Rio de Janeiro, RJ, Brazil. 6. Laboratório de Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, CEP 21.040-900, Manguinhos, Rio de Janeiro, RJ, Brazil; Centro de Pesquisa, Diagnóstico e Treinamento em Malária, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Abstract
OBJECTIVES: To report that dengue fever (DF) could have triggered Plasmodium ovale wallikeri malaria. METHODS: A retrospective case report of P. ovale malaria and DF in a single patient in Rio de Janeiro, Brazil, who had lived in Angola, is presented. RESULTS: On the second week of illness, the patient was referred to our research service. As symptoms had persisted up to day 14, malaria was also considered, based on the patient's long-standing epidemiological history. On day 16 of illness, a thick blood smear was positive for P. ovale (3480 parasites/mm(3)), PCR for malaria was positive for P. ovale wallikeri, and the kinetics of dengue virus (DENV) antibodies suggested a recent primary dengue infection. CONCLUSIONS: Concurrent infections of DENV and malaria have rarely been reported; the actual impact of these sequential or simultaneous infections remains unknown. Therefore, DF must be considered as a potential co-morbidity for malaria, because of its influence on fluid electrolyte management. The case presented showed consistent temporal, clinical, and laboratory evidence that the relapse or the long incubation period of P. ovale malaria may have been triggered by a recent DF episode. To the authors' knowledge, this is the first report of DENV and P. ovale co-infection.
OBJECTIVES: To report that dengue fever (DF) could have triggered Plasmodium ovale wallikeri malaria. METHODS: A retrospective case report of P. ovale malaria and DF in a single patient in Rio de Janeiro, Brazil, who had lived in Angola, is presented. RESULTS: On the second week of illness, the patient was referred to our research service. As symptoms had persisted up to day 14, malaria was also considered, based on the patient's long-standing epidemiological history. On day 16 of illness, a thick blood smear was positive for P. ovale (3480 parasites/mm(3)), PCR for malaria was positive for P. ovale wallikeri, and the kinetics of dengue virus (DENV) antibodies suggested a recent primary dengue infection. CONCLUSIONS: Concurrent infections of DENV and malaria have rarely been reported; the actual impact of these sequential or simultaneous infections remains unknown. Therefore, DF must be considered as a potential co-morbidity for malaria, because of its influence on fluid electrolyte management. The case presented showed consistent temporal, clinical, and laboratory evidence that the relapse or the long incubation period of P. ovale malaria may have been triggered by a recent DF episode. To the authors' knowledge, this is the first report of DENV and P. ovale co-infection.
Authors: Mateusz M Plucinski; Camelia Herman; Sophie Jones; Rafael Dimbu; Filomeno Fortes; Dragan Ljolje; Naomi Lucchi; Sean C Murphy; Nahum T Smith; Kurtis R Cruz; Annette M Seilie; Eric S Halsey; Venkatachalam Udhayakumar; Michael Aidoo; Eric Rogier Journal: J Infect Dis Date: 2019-01-09 Impact factor: 5.226