| Literature DB >> 26808576 |
Ching-Yu Yen1, Hurng-Wern Huang2, Chih-Wen Shu3, Ming-Feng Hou4, Shyng-Shiou F Yuan5, Hui-Ru Wang6, Yung-Ting Chang7, Ammad Ahmad Farooqi8, Jen-Yang Tang9, Hsueh-Wei Chang10.
Abstract
Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.Entities:
Keywords: Acetylation; Epigenetic modification; Histone; Methylation; Sugar metabolism
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Year: 2016 PMID： 26808576 DOI： 10.1016/j.canlet.2016.01.036
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679