| Literature DB >> 26807920 |
Priscila Medeiros1, Weber Laurentino da Silva1, Bruna Beatriz de Oliveira Gimenez1, Keren Bastos Vallezi1, Milton Ozório Moraes2, Vânia Niéto Brito de Souza1, Ana Carla Pereira Latini3.
Abstract
Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.Entities:
Keywords: Association study; GATA-3 transcription factor; GATA3; Leprosy; Polymorphisms; rs10905284
Mesh：
Substances：
Year: 2016 PMID： 26807920 DOI： 10.1016/j.meegid.2016.01.015
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342