Literature DB >> 26807743

Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus.

Chien-Chih Chen, Tsai-Teng Tzeng1, Chin-Chu Chen2, Ching-Li Ni, Li-Ya Lee2, Wan-Ping Chen2, Young-Ji Shiao1,3, Chien-Chang Shen3.   

Abstract

A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.

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Year:  2016        PMID： 26807743     DOI： 10.1021/acs.jnatprod.5b00474

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis.

Authors:  Shang-Yu Yang; Chi-Jung Fang; Yu-Wen Chen; Wan-Ping Chen; Li-Ya Lee; Chin-Chu Chen; Yen-You Lin; Shan-Chi Liu; Chun-Hao Tsai; Wei-Chien Huang; Yang-Chang Wu; Chih-Hsin Tang
Journal:  Nutrients       Date:  2022-06-23       Impact factor: 6.706

2.  Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

Authors:  Tzeng Tsai-Teng; Chen Chin-Chu; Lee Li-Ya; Chen Wan-Ping; Lu Chung-Kuang; Shen Chien-Chang; Huang F Chi-Ying; Chen Chien-Chih; Young-Ji Shiao
Journal:  J Biomed Sci       Date:  2016-06-27       Impact factor: 8.410

3.  The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice.

Authors:  Tsai-Teng Tzeng; Chien-Chih Chen; Chin-Chu Chen; Huey-Jen Tsay; Li-Ya Lee; Wan-Ping Chen; Chien-Chang Shen; Young-Ji Shiao
Journal:  Int J Mol Sci       Date:  2018-02-17       Impact factor: 5.923

4.  Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice.

Authors:  Chun-Hung Chiu; Charng-Cherng Chyau; Chin-Chu Chen; Li-Ya Lee; Wan-Ping Chen; Jia-Ling Liu; Wen-Hsin Lin; Mei-Chin Mong
Journal:  Int J Mol Sci       Date:  2018-01-24       Impact factor: 5.923

5.  Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum.

Authors:  Zeljka Rupcic; Monique Rascher; Sae Kanaki; Reinhard W Köster; Marc Stadler; Kathrin Wittstein
Journal:  Int J Mol Sci       Date:  2018-03-06       Impact factor: 5.923

Review 6.  Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines.

Authors:  I-Chen Li; Li-Ya Lee; Tsai-Teng Tzeng; Wan-Ping Chen; Yen-Po Chen; Young-Ju Shiao; Chin-Chu Chen
Journal:  Behav Neurol       Date:  2018-05-21       Impact factor: 3.342

7.  Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein.

Authors:  Hui-Ting Huang; Chia-Hsin Ho; Hsin-Yu Sung; Li-Ya Lee; Wan-Ping Chen; Yu-Wen Chen; Chin-Chu Chen; Chung-Shi Yang; Shun-Fen Tzeng
Journal:  Sci Rep       Date:  2021-03-22       Impact factor: 4.379

8.  Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS.

Authors:  Li-Yu Wang; Chin-Shiu Huang; Yu-Hsuan Chen; Chin-Chu Chen; Chien-Chih Chen; Cheng-Hung Chuang
Journal:  Molecules       Date:  2019-09-12       Impact factor: 4.411

Review 9.  Therapeutic Potential of Hericium erinaceus for Depressive Disorder.

Authors:  Pit Shan Chong; Man-Lung Fung; Kah Hui Wong; Lee Wei Lim
Journal:  Int J Mol Sci       Date:  2019-12-25       Impact factor: 5.923

10.  Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression.

Authors:  Pit Shan Chong; Chi Him Poon; Jaydeep Roy; Ka Chun Tsui; Sze Yuen Lew; Michael Weng Lok Phang; Rachael Julia Yuenyinn Tan; Poh Guat Cheng; Man-Lung Fung; Kah Hui Wong; Lee Wei Lim
Journal:  Chin Med       Date:  2021-12-07       Impact factor: 5.455
  10 in total

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