Literature DB >> 26807220

Reasons for cancer metastasis: A holistic perspective.

Rui-An Wang1, You-Yong Lu2, Dai-Ming Fan3.   

Abstract

Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process. These mechanisms, however, only explain the process of cancer metastasis, but do not explain why cancer would metastasize in the first place. Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis. Thus, it is crucial in medical practice to minimize the risk of cancer metastasis during a time when there are no effective means to inhibit this process.

Entities:  

Keywords:  Warburg effect; apoptosis; cancer; chemotherapy; glycolysis; hypoxia; metastasis; necrosis; radiotherapy

Year:  2015        PMID: 26807220      PMCID: PMC4665943          DOI: 10.3892/mco.2015.623

Source DB:  PubMed          Journal:  Mol Clin Oncol        ISSN: 2049-9450


  45 in total

1.  Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index.

Authors:  Grace M Callagy; Paul D Pharoah; Sarah E Pinder; Forrest D Hsu; Torsten O Nielsen; Joseph Ragaz; Ian O Ellis; David Huntsman; Carlos Caldas
Journal:  Clin Cancer Res       Date:  2006-04-15       Impact factor: 12.531

Review 2.  Rethinking the regulation of cellular metabolism.

Authors:  C B Thompson
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2012-03-19

3.  A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer.

Authors:  H Raza Ali; Sarah-Jane Dawson; Fiona M Blows; Elena Provenzano; Samuel Leung; Torsten Nielsen; Paul D Pharoah; Carlos Caldas
Journal:  J Pathol       Date:  2011-09-26       Impact factor: 7.996

4.  The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory.

Authors:  Ana M Soto; Carlos Sonnenschein
Journal:  Bioessays       Date:  2011-05       Impact factor: 4.345

5.  Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.

Authors:  Lijian Hui; Kurt Zatloukal; Harald Scheuch; Ewa Stepniak; Erwin F Wagner
Journal:  J Clin Invest       Date:  2008-11-06       Impact factor: 14.808

6.  Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis.

Authors:  John M L Ebos; Christina R Lee; William Cruz-Munoz; Georg A Bjarnason; James G Christensen; Robert S Kerbel
Journal:  Cancer Cell       Date:  2009-03-03       Impact factor: 31.743

Review 7.  Loss of Bcl-2 expression in colon cancer: a prognostic factor for recurrence in stage II colon cancer.

Authors:  Laurent Poincloux; Xavier Durando; Jean François Seitz; Emilie Thivat; Valérie-Jeanne Bardou; Marie-Hélène Giovannini; Danièle Parriaux; Nicolas Barriere; Marc Giovannini; Jean-Robert Delpero; Geneviève Monges
Journal:  Surg Oncol       Date:  2008-11-21       Impact factor: 3.279

8.  Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.

Authors:  Qian Huang; Fang Li; Xinjian Liu; Wenrong Li; Wei Shi; Fei-Fei Liu; Brian O'Sullivan; Zhimin He; Yuanlin Peng; Aik-Choon Tan; Ling Zhou; Jingping Shen; Gangwen Han; Xiao-Jing Wang; Jackie Thorburn; Andrew Thorburn; Antonio Jimeno; David Raben; Joel S Bedford; Chuan-Yuan Li
Journal:  Nat Med       Date:  2011-07-03       Impact factor: 53.440

9.  Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization.

Authors:  Wen-Quan Wang; Liang Liu; Hui-Chuan Sun; Yan-Ling Fu; Hua-Xiang Xu; Zong-Tao Chai; Qiang-Bo Zhang; Ling-Qun Kong; Xiao-Dong Zhu; Lu Lu; Zheng-Gang Ren; Zhao-You Tang
Journal:  J Hematol Oncol       Date:  2012-11-08       Impact factor: 17.388

10.  Apoptosis drives cancer cells proliferate and metastasize.

Authors:  Rui-An Wang; Qin-Long Li; Zeng-Shan Li; Ping-Ju Zheng; Hui-Zhong Zhang; Xiao-Feng Huang; Su-Min Chi; An-Gang Yang; Rutao Cui
Journal:  J Cell Mol Med       Date:  2013-01-11       Impact factor: 5.310

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  6 in total

1.  Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer.

Authors:  Athina Markou; E Tzanikou; G Kallergi; E Pantazaka; V Georgoulias; A Kotsakis; E Lianidou
Journal:  Front Cell Dev Biol       Date:  2021-04-22

2.  Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging.

Authors:  Regina Willecke-Hochmuth; Katharina Pachmann; Joachim Drevs
Journal:  Oncol Lett       Date:  2016-07-18       Impact factor: 2.967

3.  Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes.

Authors:  Jinhua Zheng; Limin Jia; Shiro Mori; Tetsuya Kodama
Journal:  BMC Cancer       Date:  2018-05-30       Impact factor: 4.430

4.  MCT4 has a potential to be used as a prognostic biomarker - a systematic review and meta-analysis.

Authors:  Arslaan Javaeed; Sanniya Khan Ghauri
Journal:  Oncol Rev       Date:  2019-07-22

5.  Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state.

Authors:  Egle Zalyte; Jonas Cicenas
Journal:  Int J Mol Med       Date:  2022-05-06       Impact factor: 5.314

6.  Epithelial-mesenchymal transition as strategic microenvironment mimicry for cancer cell survival and immune escape?

Authors:  Jun-Hui Qin; Li Wang; Qin-Long Li; Yuan Liang; Zhen-Yu Ke; Rui-An Wang
Journal:  Genes Dis       Date:  2016-11-05
  6 in total

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