Literature DB >> 26807192

Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro.

Chun-Xiao Yuan1, Takho Chu2, Li Liu3, Hao-Wen Li3, Ya-Jie Wang3, An-Chen Guo4, Yong-Ping Fan1.   

Abstract

In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 μM catalpol displayed stronger effects on OPCs migration and oligodendrocyte differentiation. These results suggest that catalpol has a potential role in promoting remyelination in demyelinating diseases, and is of therapeutic interest.

Entities:  

Keywords:  Oligodendrocytes precursor cell; catalpol; differentiation; proliferation

Year:  2015        PMID： 26807192      PMCID： PMC4697724     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  23 in total

1.  Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions.

Authors:  Heather C Wilson; Neil J Scolding; Cedric S Raine
Journal:  J Neuroimmunol       Date:  2006-06-06       Impact factor: 3.478

2.  Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway.

Authors:  Jian Hua Liang; Jing Du; Lian Deng Xu; Tao Jiang; Shuang Hao; Jing Bi; Bo Jiang
Journal:  Neurochem Int       Date:  2009-07-22       Impact factor: 3.921

Review 3.  Oligodendrocytes and the early multiple sclerosis lesion.

Authors:  John W Prineas; John D E Parratt
Journal:  Ann Neurol       Date:  2012-07       Impact factor: 10.422

4.  Protective effects of catalpol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion.

Authors:  Qi-Yan Cai; Xing-Shu Chen; Xiao-Li Zhan; Zhong-Xiang Yao
Journal:  Neurosci Lett       Date:  2011-04-16       Impact factor: 3.046

5.  In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination.

Authors:  J M Redwine; R C Armstrong
Journal:  J Neurobiol       Date:  1998-11-15

Review 6.  Deciphering the oligodendrogenic program of neural progenitors: cell intrinsic and extrinsic regulators.

Authors:  Francisco J Rivera; Carolin Steffenhagen; David Kremer; Mahesh Kandasamy; Beatrice Sandner; Sebastien Couillard-Despres; Norbert Weidner; Patrick Küry; Ludwig Aigner
Journal:  Stem Cells Dev       Date:  2010-05       Impact factor: 3.272

7.  The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS.

Authors:  Richard Reynolds; Mary Dawson; Dimitrios Papadopoulos; Annabella Polito; Isabelle Cenci Di Bello; Danielle Pham-Dinh; Joel Levine
Journal:  J Neurocytol       Date:  2002 Jul-Aug

Review 8.  Remyelination - An effective means of neuroprotection.

Authors:  Charlotte C Bruce; Chao Zhao; Robin J M Franklin
Journal:  Horm Behav       Date:  2009-06-16       Impact factor: 3.587

9.  Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons.

Authors:  Jing Bi; Bo Jiang; Shuang Hao; Aihong Zhang; Yuesheng Dong; Tao Jiang; Lijia An
Journal:  Neurochem Int       Date:  2008-12-07       Impact factor: 3.921

10.  Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.

Authors:  Stephen P J Fancy; Chao Zhao; Robin J M Franklin
Journal:  Mol Cell Neurosci       Date:  2004-11       Impact factor: 4.314
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  5 in total

1.  Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway.

Authors:  Zhaoyu Liu; Dan Xu; Shang Wang; Yi Chen; Zhen Li; Xiaoyan Gao; Lu Jiang; Yong Tang; Yan Peng
Journal:  Cell Cycle       Date:  2017-02-22       Impact factor: 4.534

2.  Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.

Authors:  Shi Hui Li; Wen Chuan Dong; Li Fan; Guang Sheng Wang
Journal:  Am J Transl Res       Date:  2016-09-15       Impact factor: 4.060

3.  Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice.

Authors:  Tao Yang; Qi Zheng; Su Wang; Ling Fang; Lei Liu; Hui Zhao; Lei Wang; Yongping Fan
Journal:  BMC Complement Altern Med       Date:  2017-05-02       Impact factor: 3.659

4.  Bu-Shen-Yi-Sui Capsule, an Herbal Medicine Formula, Promotes Remyelination by Modulating the Molecular Signals via Exosomes in Mice with Experimental Autoimmune Encephalomyelitis.

Authors:  Pei-Yuan Zhao; Jing Ji; Xi-Hong Liu; Hui Zhao; Bin Xue; Liang-Yun Jin; Yong-Ping Fan; Wen-Jing Zhao; Lei Wang
Journal:  Oxid Med Cell Longev       Date:  2020-07-22       Impact factor: 6.543

5.  Catalpol inhibits the proliferation, migration and metastasis of HCC cells by regulating miR‑140‑5p expression.

Authors:  Linsheng Wu; Haoxia Li; Shengyou Chen; Xiaoqiang Wu; Xiaomin Chen; Fangping Wang
Journal:  Mol Med Rep       Date:  2020-11-12       Impact factor: 2.952
  5 in total

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