Literature DB >> 26806457

Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice.

E A Forsberg1, H Olauson2, T Larsson2, S B Catrina3.   

Abstract

The metabolic effects of antiaging Klotho were previously investigated in vivo by genetic manipulation. We have here studied the metabolic effect of physiologic levels of circulating full length Klotho in db/db mice. Increasing the full-length human Klotho levels has a positive effect on blood glucose through increasing insulin secretion.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Glucose; Insulin and db/db mouse; Klotho; Liver

Mesh：

Substances：

Year:  2016        PMID： 26806457     DOI： 10.1016/j.diabres.2016.01.006

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  3 in total

1.  A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.

Authors:  Hugo de Luca Corrêa; Artur Temizio Oppelt Raab; Thamires Marra Araújo; Lysleine Alves Deus; Andrea Lucena Reis; Fernando Sousa Honorato; Paolo Lucas Rodrigues-Silva; Rodrigo Vanerson Passos Neves; Henver Simionato Brunetta; Marcelo Alves da Silva Mori; Octávio Luiz Franco; Thiago Dos Santos Rosa
Journal:  Sci Rep       Date:  2022-10-20       Impact factor: 4.996

2.  A single combination gene therapy treats multiple age-related diseases.

Authors:  Noah Davidsohn; Matthew Pezone; Andyna Vernet; Amanda Graveline; Daniel Oliver; Shimyn Slomovic; Sukanya Punthambaker; Xiaoming Sun; Ronglih Liao; Joseph V Bonventre; George M Church
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-04       Impact factor: 11.205

3.  Klotho Exerts an Emerging Role in Cytokinesis.

Authors:  Chiao-Yin Sun; Chi-Yuan Chou; Yu-Ying Hsieh; Kang-Chieh Lo; Yan-Liang Liou; Yau-Hung Chen
Journal:  Genes (Basel)       Date:  2020-09-04       Impact factor: 4.096
  3 in total

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