Takatoshi Tano1, Koichi Ono2, Yoshimune Hiratsuka3,4, Koji Otani5, Miho Sekiguchi5, Shinichi Konno5, Shinichi Kikuchi5, Yoshihiro Onishi6, Misa Takegami7, Masakazu Yamada8, Shunichi Fukuhara7,9, Akira Murakami3. 1. Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. 2. Department of Ophthalmology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan. 3. Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. 4. National Institute of Public Health, Saitama, Japan. 5. Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan. 6. Institute for Health Outcomes & Process Evaluation Research, Kyoto, Japan. 7. Department of Healthcare Epidemiology, School of Public Health in Graduate School of Medicine, Kyoto University, Kyoto, Japan. 8. Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan. 9. Center for Innovation in Clinical Research, Fukushima Medical University, Fukushima, Japan.
Abstract
PURPOSE: To describe the relationship between retinal vascular calibre and cardiovascular risk factors in a Japanese population. METHODS: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study is a population-based, cross-sectional survey that included 2346 persons (56.1% of the eligible population) aged 40 to 74 years old. Retinal vascular calibre was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants. RESULTS: Of the 1787 participants with available retinal vascular calibre data, the mean retinal arteriolar calibre (CRAE) was 141.6 ± 18.6 μm, the mean venular calibre (CRVE) was 209.3 ± 26.1 μm, and the mean arteriole-to-venule ratio was 0.68 ± 0.08. A smaller CRAE was associated with male sex, increasing quartiles of systolic blood pressure and diastolic blood pressure, history of hypertension, current alcohol intake and higher quartiles of serum creatinine. A larger CRAE was associated with increasing quartiles of total cholesterol. A larger CRVE was associated with current cigarette smoking. Multivariate analyses showed that a smaller CRAE was associated with male sex, elevated mean arterial blood pressure and a history of hypertension; and a larger CRVE was associated with cigarette smoking. CONCLUSIONS: The results of this study suggest that a narrowed diameter of the retinal arteriole in Japanese people is related to hypertension and sex (male) and that an enlarged retina venular diameter is related to a history of smoking. The pattern of these associations is similar to that in white populations and other Asian populations.
PURPOSE: To describe the relationship between retinal vascular calibre and cardiovascular risk factors in a Japanese population. METHODS: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study is a population-based, cross-sectional survey that included 2346 persons (56.1% of the eligible population) aged 40 to 74 years old. Retinal vascular calibre was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants. RESULTS: Of the 1787 participants with available retinal vascular calibre data, the mean retinal arteriolar calibre (CRAE) was 141.6 ± 18.6 μm, the mean venular calibre (CRVE) was 209.3 ± 26.1 μm, and the mean arteriole-to-venule ratio was 0.68 ± 0.08. A smaller CRAE was associated with male sex, increasing quartiles of systolic blood pressure and diastolic blood pressure, history of hypertension, current alcohol intake and higher quartiles of serum creatinine. A larger CRAE was associated with increasing quartiles of total cholesterol. A larger CRVE was associated with current cigarette smoking. Multivariate analyses showed that a smaller CRAE was associated with male sex, elevated mean arterial blood pressure and a history of hypertension; and a larger CRVE was associated with cigarette smoking. CONCLUSIONS: The results of this study suggest that a narrowed diameter of the retinal arteriole in Japanese people is related to hypertension and sex (male) and that an enlarged retina venular diameter is related to a history of smoking. The pattern of these associations is similar to that in white populations and other Asian populations.
Authors: Dragana Drobnjak; Inger Christine Munch; Charlotte Glümer; Kristine Færch; Line Kessel; Michael Larsen; Nina C B B Veiby Journal: J Clin Transl Endocrinol Date: 2017-03-21
Authors: Leen J Luyten; Yinthe Dockx; Eline B Provost; Narjes Madhloum; Hanne Sleurs; Kristof Y Neven; Bram G Janssen; Hannelore Bové; Florence Debacq-Chainiaux; Nele Gerrits; Wouter Lefebvre; Michelle Plusquin; Charlotte Vanpoucke; Patrick De Boever; Tim S Nawrot Journal: BMC Med Date: 2020-05-26 Impact factor: 8.775