Arcangelo Barbonetti1, Alessandra Sperandio2, Alessandro Micillo2, Settimio D'Andrea2, Federica Pacca3, Giorgio Felzani3, Sandro Francavilla2, Felice Francavilla2. 1. Andrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, L'Aquila, Italy; Spinal Unit, San Raffaele Sulmona Institute, Sulmona, Italy. Electronic address: arcangelobarbonetti@virgilio.it. 2. Andrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, L'Aquila, Italy. 3. Spinal Unit, San Raffaele Sulmona Institute, Sulmona, Italy.
Abstract
OBJECTIVE: To explore the relation between vitamin D and physical function outcomes in people with spinal cord injury (SCI). DESIGN: Cross-sectional study. SETTING: Rehabilitation institute. PARTICIPANTS: Consecutive patients (N=100; 72 men and 28 women) with chronic SCI admitted to a rehabilitation program. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Functional independence in activities of daily living (ADL) and leisure time physical activity (LTPA) were assessed as measures of physical function. RESULTS: Vitamin D deficiency (<20ng/mL) was found in 78 patients: they exhibited a significantly higher body mass index, lower functional independence in ADL, and were engaged in a significantly poorer weekly LTPA. At the linear multiple regression analysis, lower 25-hydroxyvitamin D levels showed significant independent associations with poorer functional independence in ADL (β=.59; 95% confidence interval, .36-.82; P<.0001) and with poorer LTPA (β=2.35; 95% confidence interval, 0.77-3.94; P=.004), after adjustment for other predictors of physical function outcomes selected by univariate analyses. CONCLUSIONS: In people with chronic SCI, a low vitamin D level represents an independent predictor of poor physical function.
OBJECTIVE: To explore the relation between vitamin D and physical function outcomes in people with spinal cord injury (SCI). DESIGN: Cross-sectional study. SETTING: Rehabilitation institute. PARTICIPANTS: Consecutive patients (N=100; 72 men and 28 women) with chronic SCI admitted to a rehabilitation program. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Functional independence in activities of daily living (ADL) and leisure time physical activity (LTPA) were assessed as measures of physical function. RESULTS:Vitamin D deficiency (<20ng/mL) was found in 78 patients: they exhibited a significantly higher body mass index, lower functional independence in ADL, and were engaged in a significantly poorer weekly LTPA. At the linear multiple regression analysis, lower 25-hydroxyvitamin D levels showed significant independent associations with poorer functional independence in ADL (β=.59; 95% confidence interval, .36-.82; P<.0001) and with poorer LTPA (β=2.35; 95% confidence interval, 0.77-3.94; P=.004), after adjustment for other predictors of physical function outcomes selected by univariate analyses. CONCLUSIONS: In people with chronic SCI, a low vitamin D level represents an independent predictor of poor physical function.
Authors: S D'Andrea; A Martorella; F Coccia; C Castellini; E Minaldi; M Totaro; A Parisi; F Francavilla; S Francavilla; A Barbonetti Journal: Endocrine Date: 2020-09-03 Impact factor: 3.633
Authors: A Barbonetti; S D'Andrea; J Samavat; A Martorella; G Felzani; S Francavilla; M Luconi; F Francavilla Journal: J Endocrinol Invest Date: 2018-05-04 Impact factor: 4.256
Authors: Samuel Amorim; Vitor Hugo Teixeira; Rui Corredeira; Maria Cunha; Bruno Maia; Paulo Margalho; Joana Pires Journal: J Spinal Cord Med Date: 2017-09-13 Impact factor: 1.985
Authors: Palak Walia; Rebekah L Goldstein; Merilee Teylan; Antonio A Lazzari; Jaime E Hart; Carlos G Tun; Eric Garshick Journal: J Spinal Cord Med Date: 2017-10-09 Impact factor: 1.985