Ricardo Jorge Dinis-Oliveira1. 1. Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. ricardinis@sapo.pt.
Abstract
BACKGROUND: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile. OBJECTIVE: This work performs a complete review of the metabolism of ethanol focusing on both major and minor metabolites. METHOD: An exhaustive literature search was carried out using textual and structural queries for ethanol and related known metabolizing enzymes and metabolites. RESULTS: The main pathway of metabolism is catalyzed by cytosolic alcohol dehydrogenase, which exhibits multiple isoenzymes and genetic polymorphisms with clinical and forensic implications. Another two oxidative routes, the highly inducible CYP2E1 system and peroxisomal catalase may acquire relevance under specific circumstances. In addition to oxidative metabolism, ethanol also originates minor metabolites such as ethyl glucuronide, ethyl sulfate, ethyl phosphate, ethyl nitrite, phosphatidylethanol and fatty acid ethyl esters. These metabolites represent alternative biomarkers since they can be detected several hours or days after ethanol exposure. CONCLUSION: It is expected that knowing the metabolomics of ethanol may provide additional insights to better understand the toxicological effects and the variability of dose response.
BACKGROUND: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile. OBJECTIVE: This work performs a complete review of the metabolism of ethanol focusing on both major and minor metabolites. METHOD: An exhaustive literature search was carried out using textual and structural queries for ethanol and related known metabolizing enzymes and metabolites. RESULTS: The main pathway of metabolism is catalyzed by cytosolic alcohol dehydrogenase, which exhibits multiple isoenzymes and genetic polymorphisms with clinical and forensic implications. Another two oxidative routes, the highly inducible CYP2E1 system and peroxisomal catalase may acquire relevance under specific circumstances. In addition to oxidative metabolism, ethanol also originates minor metabolites such as ethyl glucuronide, ethyl sulfate, ethyl phosphate, ethyl nitrite, phosphatidylethanol and fatty acid ethyl esters. These metabolites represent alternative biomarkers since they can be detected several hours or days after ethanol exposure. CONCLUSION: It is expected that knowing the metabolomics of ethanol may provide additional insights to better understand the toxicological effects and the variability of dose response.
Authors: Qian Xiao; Andriy Derkach; Steven C Moore; Wei Zheng; Xiao-Ou Shu; Fangyi Gu; Neil E Caporaso; Joshua N Sampson; Charles E Matthews Journal: Metabolomics Date: 2017-04-06 Impact factor: 4.290
Authors: Ivan M Petyaev; Marina P Chernyshova; Dmitry V Pristensky; Natalia E Chalyk; Victor A Klochkov; Nigel H Kyle; Yuriy K Bashmakov Journal: Adv Prev Med Date: 2018-07-30
Authors: Marco Rossi; Muhammad Jahanzaib Anwar; Ahmad Usman; Ali Keshavarzian; Faraz Bishehsari Journal: Cancers (Basel) Date: 2018-01-30 Impact factor: 6.639