| Literature DB >> 26804758 |
Rasnik K Singh1, Kristina M Lee2, Ivan Vujkovic-Cvijin3, Derya Ucmak2, Benjamin Farahnik4, Michael Abrouk5, Mio Nakamura6, Tian Hao Zhu7, Tina Bhutani2, Maria Wei2, Wilson Liao2.
Abstract
IL-17 is involved in the pathogenesis of several autoimmune diseases; however its role in vitiligo has not been well defined. Emerging human and mouse studies have demonstrated that systemic, tissue, and cellular levels of IL-17 are elevated in vitiligo. Many studies have also shown significant positive correlations between these levels and disease activity, extent, and severity. Treatments that improve vitiligo, such as ultraviolet B phototherapy, also modulate IL-17 levels. This review synthesizes our current understanding of how IL-17 may influence the pathogenesis of autoimmune vitiligo at the molecular level. This has implications for defining new vitiligo biomarkers and treatments.Entities:
Keywords: IL-17; Interleukin-17; Vitiligo
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Year: 2016 PMID： 26804758 PMCID： PMC4769658 DOI： 10.1016/j.autrev.2016.01.004
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754