Literature DB >> 26804252

Stem Cells in the Limbal Stroma.

James L Funderburgh1, Martha L Funderburgh2, Yiqin Du2.   

Abstract

The corneal stroma contains a population of mesenchymal cells subjacent to the limbal basement membrane with characteristics of adult stem cells. These 'niche cells' support limbal epithelial stem cell viability. In culture by themselves, the niche cells display a phenotype typical of mesenchymal stem cells. These stromal stem cells exhibit a potential to differentiate to multiple cell types, including keratocytes, thus providing an abundant source of these rare cells for experimental and bioengineering applications. Stromal stem cells have also shown the ability to remodel pathological stromal tissue, suppressing inflammation and restoring transparency. Because stromal stem cells can be obtained by biopsy, they offer a potential for autologous stem cell treatment for stromal opacities. This review provides an overview of the status of work on this interesting cell population.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  bioengineering; cell-based therapy; cornea; limbus; stem cells; stroma

Mesh：

Year:  2016        PMID： 26804252      PMCID： PMC4842326          DOI： 10.1016/j.jtos.2015.12.006

Source DB:  PubMed          Journal:  Ocul Surf        ISSN： 1542-0124            Impact factor:   5.033


  73 in total

Review 1.  Keratocyte and fibroblast phenotypes in the repairing cornea.

Authors:  M E Fini
Journal:  Prog Retin Eye Res       Date:  1999-07       Impact factor: 21.198

2.  Limbal epithelial stem/progenitor cells attract stromal niche cells by SDF-1/CXCR4 signaling to prevent differentiation.

Authors:  Hua-Tao Xie; Szu-Yu Chen; Gui-Gang Li; Scheffer C G Tseng
Journal:  Stem Cells       Date:  2011-11       Impact factor: 6.277

Review 3.  Chemokines and adult bone marrow stem cells.

Authors:  Sara M Rankin
Journal:  Immunol Lett       Date:  2012-07-30       Impact factor: 3.685

4.  A new isolation method of human limbal progenitor cells by maintaining close association with their niche cells.

Authors:  Szu-Yu Chen; Yasutaka Hayashida; Mei-Yun Chen; Hua Tao Xie; Scheffer C G Tseng
Journal:  Tissue Eng Part C Methods       Date:  2011-02-14       Impact factor: 3.056

5.  PAX6 expression identifies progenitor cells for corneal keratocytes.

Authors:  Martha L Funderburgh; Yiqin Du; Mary M Mann; Nirmala SundarRaj; James L Funderburgh
Journal:  FASEB J       Date:  2005-05-18       Impact factor: 5.191

Review 6.  Immune responses after mesenchymal stem cell implantation.

Authors:  Rony Atoui; Ray C J Chiu
Journal:  Methods Mol Biol       Date:  2013

7.  In vivo confocal microscopic analysis of normal human anterior limbal stroma.

Authors:  Saumi Mathews; Jaya Devi Chidambaram; Shruti Lanjewar; Jeena Mascarenhas; Namperumalsamy Venkatesh Prajna; Veerappan Muthukkaruppan; Gowri Priya Chidambaranathan
Journal:  Cornea       Date:  2015-04       Impact factor: 2.651

8.  Corneal stromal and endothelial cell precursors.

Authors:  Shiro Amano; Satoru Yamagami; Tatsuya Mimura; Saiko Uchida; Seiichi Yokoo
Journal:  Cornea       Date:  2006-12       Impact factor: 2.651

9.  Altered KSPG expression by keratocytes following corneal injury.

Authors:  Eric C Carlson; I-Jong Wang; Chia-Yang Liu; Paul Brannan; Candace W C Kao; Winston W Y Kao
Journal:  Mol Vis       Date:  2003-11-21       Impact factor: 2.367

Review 10.  Heart regeneration, stem cells, and cytokines.

Authors:  Na Li; Chuan Wang; LiXin Jia; Jie Du
Journal:  Regen Med Res       Date:  2014-04-02
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  38 in total

Review 1.  Corneal injury: Clinical and molecular aspects.

Authors:  Brayden Barrientez; Sarah E Nicholas; Amy Whelchel; Rabab Sharif; Jesper Hjortdal; Dimitrios Karamichos
Journal:  Exp Eye Res       Date:  2019-06-22       Impact factor: 3.467

Review 2.  Explant culture: An advantageous method for isolation of mesenchymal stem cells from human tissues.

Authors:  Fatemeh Hendijani
Journal:  Cell Prolif       Date:  2017-02-01       Impact factor: 6.831

Review 3.  Multipotent Differentiation of Human Dental Pulp Stem Cells: a Literature Review.

Authors:  N Nuti; C Corallo; B M F Chan; M Ferrari; B Gerami-Naini
Journal:  Stem Cell Rev Rep       Date:  2016-10       Impact factor: 5.739

Review 4.  Limbal and corneal epithelial homeostasis.

Authors:  Ghasem Yazdanpanah; Sayena Jabbehdari; Ali R Djalilian
Journal:  Curr Opin Ophthalmol       Date:  2017-07       Impact factor: 3.761

Review 5.  Regenerative therapy for the Cornea.

Authors:  Ajay Kumar; Hongmin Yun; Martha L Funderburgh; Yiqin Du
Journal:  Prog Retin Eye Res       Date:  2021-09-14       Impact factor: 21.198

6.  Isolation and ex vivo Expansion of Limbal Mesenchymal Stromal Cells.

Authors:  Naresh Polisetti; Lyne Sharaf; Thomas Reinhard; Günther Schlunck
Journal:  Bio Protoc       Date:  2022-07-20

7.  Effect of Conditioned Media of Limbal Epithelial Cells and Corneal Stromal Cells on Functional Activity of Limb Mesenchymal Stem Cells.

Authors:  N A Bondarenko; M A Surovtseva; I I Kim; A P Lykov; I A Iskakov; A N Trunov; V V Chernykh; O V Poveshchenko
Journal:  Bull Exp Biol Med       Date:  2022-09-05       Impact factor: 0.737

Review 8.  The diagnosis of limbal stem cell deficiency.

Authors:  Qihua Le; Jianjiang Xu; Sophie X Deng
Journal:  Ocul Surf       Date:  2017-11-04       Impact factor: 5.033

Review 9.  Limbal stem cells: identity, developmental origin, and therapeutic potential.

Authors:  Gabriel Gonzalez; Yuzuru Sasamoto; Bruce R Ksander; Markus H Frank; Natasha Y Frank
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2017-11-03       Impact factor: 5.814

Review 10.  Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation.

Authors:  Vivek Singh; Anil Tiwari; Abhinav Reddy Kethiri; Virender Singh Sangwan
Journal:  Stem Cells Transl Med       Date:  2021-05-05       Impact factor: 6.940
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