| Literature DB >> 26803729 |
Christina Piperi1, Christos Adamopoulos1, Athanasios G Papavassiliou2.
Abstract
X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.Entities:
Keywords: X-box binding protein 1; glucose; lipogenesis; metabolic diseases; unfolded protein response
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Year: 2016 PMID： 26803729 DOI： 10.1016/j.tem.2016.01.001
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015