Matteo Tonna1, Rebecca Ottoni2, Francesca Paglia2, Paolo Ossola2, Chiara De Panfilis3, Carlo Marchesi3. 1. Department of Mental Health, Local Health Service, Parma, Italy. Electronic address: mtonna@ausl.pr.it. 2. Department of Neuroscience, Psychiatric Unit, University of Parma, Italy. 3. Department of Neuroscience, Psychiatric Unit, University of Parma, Italy; Department of Mental Health, Local Health Service, Parma, Italy.
Abstract
OBJECTIVE: Recent research has suggested a dual impact of obsessive-compulsive dimension on functioning in schizophrenia with a gradual transition from an improving to a worsening effect depending on obsessive-compulsive symptoms (OCS) severity (from mild to moderate-severe). Aim of the present study was to investigate whether this varying effect of OCS on functioning might be mediated or moderated by schizophrenia symptom dimensions or occur independently. METHOD: Seventy-five patients affected by schizophrenia were administered the Structured Clinical Interview for DSM-IV Disorders, the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale and the Social and Occupational Functioning Assessment. The sample was divided into two groups according to the severity of OCS (absent/mild and moderate/high OCS group). RESULTS: In both groups, the effect of OCS on functioning was not mediated by their effect on positive, negative or disorganization symptoms. Conversely, a significant interaction between OCS and disorganization dimension was found: the dual effect of OCS on functioning occurred only among patients with low disorganization symptoms while it was no more apparent at high levels of disorganization. CONCLUSION: Data suggest that in patients with schizophrenia, functioning at least in part depends on the interaction between disorganization and OCS.
OBJECTIVE: Recent research has suggested a dual impact of obsessive-compulsive dimension on functioning in schizophrenia with a gradual transition from an improving to a worsening effect depending on obsessive-compulsive symptoms (OCS) severity (from mild to moderate-severe). Aim of the present study was to investigate whether this varying effect of OCS on functioning might be mediated or moderated by schizophrenia symptom dimensions or occur independently. METHOD: Seventy-five patients affected by schizophrenia were administered the Structured Clinical Interview for DSM-IV Disorders, the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale and the Social and Occupational Functioning Assessment. The sample was divided into two groups according to the severity of OCS (absent/mild and moderate/high OCS group). RESULTS: In both groups, the effect of OCS on functioning was not mediated by their effect on positive, negative or disorganization symptoms. Conversely, a significant interaction between OCS and disorganization dimension was found: the dual effect of OCS on functioning occurred only among patients with low disorganization symptoms while it was no more apparent at high levels of disorganization. CONCLUSION: Data suggest that in patients with schizophrenia, functioning at least in part depends on the interaction between disorganization and OCS.
Authors: Yong-Ming Wang; Lai-Quan Zou; Wen-Lan Xie; Zhuo-Ya Yang; Xiong-Zhao Zhu; Eric F C Cheung; Thomas Alrik Sørensen; Arne Møller; Raymond C K Chan Journal: Schizophr Bull Date: 2019-01-01 Impact factor: 9.306
Authors: Hai-Di Shan; Yong-Ming Wang; Hui-Xin Hu; Shu-Yao Jiang; Min-Yi Chu; Yi Wang; Simon S Y Lui; Eric F C Cheung; Zhen Wang; Raymond C K Chan Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-01-03 Impact factor: 5.270