Alice Breining1,2, Jean-Sébastien Silvestre3, Bénédicte Dieudonné4, José Vilar3, Véronique Faucounau4, Marc Verny4,5, Christian Néri5, Chantal M Boulanger3, Jacques Boddaert4,5. 1. Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France. alice.breining@aphp.fr. 2. Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8256 B2A, 75005, Paris, France. alice.breining@aphp.fr. 3. INSERM, U970, Paris Cardiovascular Research Center-PARCC, Université Paris Descartes, Sorbonne Paris Cité, UMR-S970, Paris, France. 4. Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France. 5. Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8256 B2A, 75005, Paris, France.
Abstract
BACKGROUND: Several studies have suggested that vascular dysfunction plays an important role in Alzheimer's disease. AIMS: We hypothesized that significant differences might be observed in the levels of blood endothelial biomarkers across elderly population of subjects with dementia. METHODS: We analyzed, in a prospective monocentric study, three different endothelial biomarkers, endothelial microparticles (EMPs), endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in 132 older patients who underwent a full evaluation of a memory complaint. RESULTS: There was no difference in specific EMP, EPC or CEC levels between demented or non-demented patients, nor considering cognitive decline. DISCUSSION: Blood endothelial biomarkers may be too sensitive and it is likely that the multimorbidity observed in our patients may lead to opposite and confounding effects on endothelial biomarkers levels. CONCLUSION: Unlike younger AD patients, our results suggest that endothelial biomarkers are not valuable for the diagnosis of dementia in elderly patients.
BACKGROUND: Several studies have suggested that vascular dysfunction plays an important role in Alzheimer's disease. AIMS: We hypothesized that significant differences might be observed in the levels of blood endothelial biomarkers across elderly population of subjects with dementia. METHODS: We analyzed, in a prospective monocentric study, three different endothelial biomarkers, endothelial microparticles (EMPs), endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in 132 older patients who underwent a full evaluation of a memory complaint. RESULTS: There was no difference in specific EMP, EPC or CEC levels between demented or non-demented patients, nor considering cognitive decline. DISCUSSION: Blood endothelial biomarkers may be too sensitive and it is likely that the multimorbidity observed in our patients may lead to opposite and confounding effects on endothelial biomarkers levels. CONCLUSION: Unlike younger ADpatients, our results suggest that endothelial biomarkers are not valuable for the diagnosis of dementia in elderly patients.
Authors: Daniel A Nation; Alick Tan; Shubir Dutt; Elissa C McIntosh; Belinda Yew; Jean K Ho; Anna E Blanken; Jung Yun Jang; Kathleen E Rodgers; Aimée Gaubert Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Antía Custodia; Alberto Ouro; Daniel Romaus-Sanjurjo; Juan Manuel Pías-Peleteiro; Helga E de Vries; José Castillo; Tomás Sobrino Journal: Front Aging Neurosci Date: 2022-01-26 Impact factor: 5.750