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Literature DB >> 26802048

ε-globin expression is regulated by SUV4-20h1.

Yadong Wang¹, Gerhard Rank², Zhuchen Li¹, Ying Wang¹, Junyi Ju¹, Alexander Nuber³, Yupeng Wu¹, Ming Liu¹, Min Nie¹, Feifei Huang¹, Loretta Cerruti², Chi Ma¹, Renxiang Tan¹, Gunnar Schotta³, Stephen M Jane², Changjiang K Zeng⁴, Quan Zhao⁵.

Abstract

Entities: Gene

Keywords: DNA methylation; SUV4-20h1; histone methylation; β-thalassemia; ε-globin

Mesh：

Substances：

Year: 2016 PMID： 26802048 PMCID： PMC5004379 DOI： 10.3324/haematol.2015.139980

Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941

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15 in total

Review 1. Evolutionary strategies for the elucidation of cis and trans factors that regulate the developmental switching programs of the beta-like globin genes.

Authors: D L Gumucio; D A Shelton; W Zhu; D Millinoff; T Gray; J H Bock; J L Slightom; M Goodman
Journal: Mol Phylogenet Evol Date: 1996-02 Impact factor: 4.286

2. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes.

Authors: Shuaiying Cui; Osamu Tanabe; Michael Sierant; Lihong Shi; Andrew Campbell; Kim-Chew Lim; James Douglas Engel
Journal: Blood Date: 2015-01-05 Impact factor: 22.113

3. Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.

Authors: K Tanimoto; Q Liu; F Grosveld; J Bungert; J D Engel
Journal: Genes Dev Date: 2000-11-01 Impact factor: 11.361

4. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

Authors: Quan Zhao; Gerhard Rank; Yuen T Tan; Haitao Li; Robert L Moritz; Richard J Simpson; Loretta Cerruti; David J Curtis; Dinshaw J Patel; C David Allis; John M Cunningham; Stephen M Jane
Journal: Nat Struct Mol Biol Date: 2009-02-22 Impact factor: 15.369

5. A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease.

Authors: Zhenning He; J Eric Russell
Journal: Proc Natl Acad Sci U S A Date: 2002-07-17 Impact factor: 11.205

6. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Authors: Gunnar Schotta; Roopsha Sengupta; Stefan Kubicek; Stephen Malin; Monika Kauer; Elsa Callén; Arkady Celeste; Michaela Pagani; Susanne Opravil; Inti A De La Rosa-Velazquez; Alexsandra Espejo; Mark T Bedford; André Nussenzweig; Meinrad Busslinger; Thomas Jenuwein
Journal: Genes Dev Date: 2008-08-01 Impact factor: 11.361

ε-globin expression is regulated by SUV4-20h1.

Review 1. Evolutionary strategies for the elucidation of cis and trans factors that regulate the developmental switching programs of the beta-like globin genes.

2. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes.

3. Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.

4. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

5. A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease.

6. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Review 7. Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies.

8. Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins.

Review 9. Epigenetic regulation of fetal globin gene expression in adult erythroid cells.

10. GATA1 and YY1 are developmental repressors of the human epsilon-globin gene.

1. Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression.