BACKGROUND:Inflammatory markers, adiponectin, and movement/nonmovement behaviors have all been linked to risk factors for cardiovascular disease; however, the association between childhood movement/nonmovement behaviors and inflammatory markers and adiponectin is unknown. METHODS: We explored the association between accelerometer determined moderate-to-vigorous physical activity (MVPA), sedentary time, and sleep (7 days/8 nights) and fasting C-reactive protein (CRP), interleukin-6 (IL-6), and adiponectin in 806 school children. A sleep variability score was calculated. RESULTS:MVPA was negatively associated with adiponectin in boys and girls (P < .001) and with CRP and IL-6 in girls (P < .05) independent of sleep duration, sedentary time, age, fat mass index (FMI), and pubertal status. Sedentary time was positively associated with adiponectin in boys and girls (both P < .001), and sleep duration with adiponectin in boys independent of age, FMI, and pubertal status (P < .001); however, these associations disappeared after mutual adjustments for movement behavior. Sleep duration variability was positively associated with CRP in girls independent of all covariates (P < .01). CONCLUSION:MVPA remained negatively associated with inflammatory markers and adiponectin, and sleep duration variability positively associated with CRP after adjustment for FMI, pubertal status, and other movement behavior. The inverse association between MVPA and adiponectin conflicts with the anti-inflammatory properties of adiponectin.
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BACKGROUND: Inflammatory markers, adiponectin, and movement/nonmovement behaviors have all been linked to risk factors for cardiovascular disease; however, the association between childhood movement/nonmovement behaviors and inflammatory markers and adiponectin is unknown. METHODS: We explored the association between accelerometer determined moderate-to-vigorous physical activity (MVPA), sedentary time, and sleep (7 days/8 nights) and fasting C-reactive protein (CRP), interleukin-6 (IL-6), and adiponectin in 806 school children. A sleep variability score was calculated. RESULTS: MVPA was negatively associated with adiponectin in boys and girls (P < .001) and with CRP and IL-6 in girls (P < .05) independent of sleep duration, sedentary time, age, fat mass index (FMI), and pubertal status. Sedentary time was positively associated with adiponectin in boys and girls (both P < .001), and sleep duration with adiponectin in boys independent of age, FMI, and pubertal status (P < .001); however, these associations disappeared after mutual adjustments for movement behavior. Sleep duration variability was positively associated with CRP in girls independent of all covariates (P < .01). CONCLUSION: MVPA remained negatively associated with inflammatory markers and adiponectin, and sleep duration variability positively associated with CRP after adjustment for FMI, pubertal status, and other movement behavior. The inverse association between MVPA and adiponectin conflicts with the anti-inflammatory properties of adiponectin.
Authors: Monica R Ordway; Eileen M Condon; Bridget Basile Ibrahim; Emily A Abel; Melissa C Funaro; Janene Batten; Lois S Sadler; Nancy S Redeker Journal: Sleep Med Rev Date: 2021-05-01 Impact factor: 11.401
Authors: Mark A Ferro; Ellen L Lipman; Ryan J Van Lieshout; Jan Willem Gorter; Lilly Shanahan; Michael Boyle; Kathy Georgiades; Brian Timmons Journal: BMJ Open Date: 2019-11-03 Impact factor: 2.692
Authors: Elissa K Hoopes; Michele N D'Agata; Felicia R Berube; Sushant M Ranadive; Freda Patterson; William B Farquhar; David G Edwards; Melissa A Witman Journal: Brain Behav Immun Health Date: 2021-02-28
Authors: Ming Hui Li; Cindy Hui Ping Sit; Stephen Heung Sang Wong; Yun Kwok Wing; Ching Kong Ng; James Rudd; Jia Yi Chow; Raymond Kim Wai Sum Journal: Front Public Health Date: 2022-09-20
Authors: Nicholas Kuzik; Veronica J Poitras; Mark S Tremblay; Eun-Young Lee; Stephen Hunter; Valerie Carson Journal: BMC Public Health Date: 2017-11-20 Impact factor: 3.295