| Literature DB >> 26800309 |
Stuart T Onions1, Kazuhiro Ito2, Catherine E Charron2, Richard J Brown1, Marie Colucci1, Fritz Frickel2, George Hardy2, Kevin Joly1, John King-Underwood3, Yasuo Kizawa4, Ian Knowles5, P John Murray2, Andrew Novak1, Anjna Rani1, Garth Rapeport2, Alun Smith1, Peter Strong2, David M Taddei1, Jonathan G Williams1.
Abstract
The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.Entities:
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Year: 2016 PMID： 26800309 DOI： 10.1021/acs.jmedchem.5b01029
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446