PURPOSE: To evaluate the regenerative results of the addition of bone marrow aspirate concentrate, using a single or double centrifugation protocol, to a xenogeneic bone graft in sinus floor elevation. MATERIALS AND METHODS: Using a randomized, controlled pilot study design in 15 consecutive patients, sinus floor elevation procedures were performed with a xenogenous bone graft alone (control group, CG) or associated with bone marrow aspirate concentrate obtained by single centrifugation (single centrifugation group, SCG) or double centrifugation (double centrifugation group, DCG). In the patients in the single and double centrifugation groups, bone marrow was harvested from the iliac bone. Six months after the grafting procedures, bone biopsy specimens were obtained during implant placement and were analyzed by histomorphometry. RESULTS: Histomorphometric analysis revealed a great amount of vital mineralized tissue in SCG followed by DCG when compared with the CG (38.44 ± 12.34%, 34.63 ± 9.84%, and 27.30 ± 5.55%, respectively). SCG and DCG presented smaller amounts of nonvital mineralized tissue when compared with the CG (13.70 ± 7.50%, 19.63 ± 8.35%, and 22.79 ± 9.60%, respectively), thus presenting higher levels of resorption. Although these differences were not statistically significant (P > .05), a tendency toward bone gain in the experimental groups (SCG and DCG) was found. All groups (SCG, DCG, and CG) showed similar levels of nonmineralized tissue (47.87 ± 6.31%, 45.73 ± 7.33%, and 49.90 ± 7.64%, respectively). CONCLUSION: This pilot study indicates that the clinical use of bone marrow aspirate concentrate, obtained by either a single or double centrifugation process, combined with a xenograft for maxillary sinus elevation seems to result in more adequate bone repair. However, clinical trials with a larger number of patients are required.
RCT Entities:
PURPOSE: To evaluate the regenerative results of the addition of bone marrow aspirate concentrate, using a single or double centrifugation protocol, to a xenogeneic bone graft in sinus floor elevation. MATERIALS AND METHODS: Using a randomized, controlled pilot study design in 15 consecutive patients, sinus floor elevation procedures were performed with a xenogenous bone graft alone (control group, CG) or associated with bone marrow aspirate concentrate obtained by single centrifugation (single centrifugation group, SCG) or double centrifugation (double centrifugation group, DCG). In the patients in the single and double centrifugation groups, bone marrow was harvested from the iliac bone. Six months after the grafting procedures, bone biopsy specimens were obtained during implant placement and were analyzed by histomorphometry. RESULTS: Histomorphometric analysis revealed a great amount of vital mineralized tissue in SCG followed by DCG when compared with the CG (38.44 ± 12.34%, 34.63 ± 9.84%, and 27.30 ± 5.55%, respectively). SCG and DCG presented smaller amounts of nonvital mineralized tissue when compared with the CG (13.70 ± 7.50%, 19.63 ± 8.35%, and 22.79 ± 9.60%, respectively), thus presenting higher levels of resorption. Although these differences were not statistically significant (P > .05), a tendency toward bone gain in the experimental groups (SCG and DCG) was found. All groups (SCG, DCG, and CG) showed similar levels of nonmineralized tissue (47.87 ± 6.31%, 45.73 ± 7.33%, and 49.90 ± 7.64%, respectively). CONCLUSION: This pilot study indicates that the clinical use of bone marrow aspirate concentrate, obtained by either a single or double centrifugation process, combined with a xenograft for maxillary sinus elevation seems to result in more adequate bone repair. However, clinical trials with a larger number of patients are required.
Authors: Bálint Trimmel; Noémi Gede; Péter Hegyi; Zsolt Szakács; Gyöngyi Anna Mezey; Eszter Varga; Márton Kivovics; Lilla Hanák; Zoltán Rumbus; György Szabó Journal: Clin Oral Implants Res Date: 2021-01-06 Impact factor: 5.977
Authors: Marco Cicciù; Gabriele Cervino; Alan Scott Herford; Fausto Famà; Ennio Bramanti; Luca Fiorillo; Floriana Lauritano; Sergio Sambataro; Giuseppe Troiano; Luigi Laino Journal: Mar Drugs Date: 2018-01-13 Impact factor: 5.118
Authors: Ruggero Rodriguez Y Baena; Riccardo D'Aquino; Antonio Graziano; Letizia Trovato; Antonio C Aloise; Gabriele Ceccarelli; Gabriella Cusella; André A Pelegrine; Saturnino M Lupi Journal: Front Cell Dev Biol Date: 2017-09-27