Literature DB >> 2680002

Alzheimer's disease: environmental factors and etiologic hypotheses.

D Gautrin1, S Gauthier.   

Abstract

A review of published reports on conventional and unconventional viruses, aluminum, neurotoxic metals and trace elements, neurotoxins of biological origin and immune systems, suggest that environmental factors, possibly multiple ones, play a significant role in the etiology of Alzheimer's disease. A complex interaction between genetic predisposition to this illness, natural aging processes, environmental factors over a life-time exposure and pathological alterations of the host immune system is proposed.

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Year:  1989        PMID： 2680002     DOI： 10.1017/s0317167100029425

Source DB:  PubMed          Journal:  Can J Neurol Sci        ISSN： 0317-1671            Impact factor:   2.104


  8 in total

Review 1.  On the issue of transmissibility of Alzheimer disease: a critical review.

Authors:  Christian Schmidt; André Karch; Carsten Korth; Inga Zerr
Journal:  Prion       Date:  2012-10-10       Impact factor: 3.931

2.  Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

Authors:  G W Roberts; S M Gentleman; A Lynch; L Murray; M Landon; D I Graham
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-04       Impact factor: 10.154

Review 3.  Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes.

Authors:  Ke Hao; Antonio Fabio Di Narzo; Lap Ho; Wei Luo; Shuyu Li; Rong Chen; Tongbin Li; Lauren Dubner; Giulio Maria Pasinetti
Journal:  Mol Aspects Med       Date:  2015-06-23

4.  Genetic influences on tissue deposition of aluminum in mice.

Authors:  G J Fosmire; S J Focht; G E McClearn
Journal:  Biol Trace Elem Res       Date:  1993 May-Jun       Impact factor: 3.738

5.  Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression.

Authors:  W S Griffin; J G Sheng; S M Gentleman; D I Graham; R E Mrak; G W Roberts
Journal:  Neurosci Lett       Date:  1994-08-01       Impact factor: 3.046

Review 6.  Glial cytokines in Alzheimer's disease: review and pathogenic implications.

Authors:  R E Mrak; J G Sheng; W S Griffin
Journal:  Hum Pathol       Date:  1995-08       Impact factor: 3.466

Review 7.  Potential role of viruses in neurodegeneration.

Authors:  K Kristensson
Journal:  Mol Chem Neuropathol       Date:  1992 Feb-Apr

8.  Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb.

Authors:  E M Barnett; M D Cassell; S Perlman
Journal:  Neuroscience       Date:  1993-12       Impact factor: 3.590
  8 in total

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