Literature DB >> 26798124

Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function.

Ingrid Dahlman1, Mikael Rydén2, David Brodin3, Harald Grallert4, Rona J Strawbridge5, Peter Arner1.   

Abstract

Central fat accumulation is a strong risk factor for type 2 diabetes. Genome-wide association studies have identified numerous loci associated with body fat distribution. The objectives of the current study are to examine whether genes in genetic loci linked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue function. We show, in a cohort of 114 women, that almost half of the 96 genes in these loci are indeed associated with abdominal subcutaneous adipose tissue parameters. Thus, adipose mRNA expression of the genes is strongly related to adipose morphology, catecholamine-induced lipid mobilization (lipolysis), or insulin-stimulated lipid synthesis in adipocytes (lipogenesis). In conclusion, the genetic influence on body fat distribution could be mediated via several specific alterations in adipose tissue morphology and function, which in turn may influence the development of type 2 diabetes.
© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Year:  2016        PMID： 26798124     DOI： 10.2337/db15-0828

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  22 in total

1.  Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes.

Authors:  Kelvin H M Kwok; Mikael Rydén; Daniel P Andersson; Gallic Beauchef; Christelle Guere; Katell Vie; Otto Bergman; Veroniqa Lundbäck; Peter Arner; Ingrid Dahlman
Journal:  Int J Obes (Lond)       Date:  2019-06-04       Impact factor: 5.095

Review 2.  Determinants of body fat distribution in humans may provide insight about obesity-related health risks.

Authors:  Aaron P Frank; Roberta de Souza Santos; Biff F Palmer; Deborah J Clegg
Journal:  J Lipid Res       Date:  2018-08-10       Impact factor: 5.922

Review 3.  Adipose tissue: between the extremes.

Authors:  Alexandros Vegiopoulos; Maria Rohm; Stephan Herzig
Journal:  EMBO J       Date:  2017-06-16       Impact factor: 11.598

Review 4.  Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes.

Authors:  Chatchalit Rattarasarn
Journal:  Adipocyte       Date:  2018-02-07       Impact factor: 4.534

5.  Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

Authors:  Luca A Lotta; Laura B L Wittemans; Verena Zuber; Isobel D Stewart; Stephen J Sharp; Jian'an Luan; Felix R Day; Chen Li; Nicholas Bowker; Lina Cai; Emanuella De Lucia Rolfe; Kay-Tee Khaw; John R B Perry; Stephen O'Rahilly; Robert A Scott; David B Savage; Stephen Burgess; Nicholas J Wareham; Claudia Langenberg
Journal:  JAMA       Date:  2018-12-25       Impact factor: 56.272

6.  Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

Authors:  Luca A Lotta; Pawan Gulati; Felix R Day; Felicity Payne; Halit Ongen; Martijn van de Bunt; Kyle J Gaulton; John D Eicher; Stephen J Sharp; Jian'an Luan; Emanuella De Lucia Rolfe; Isobel D Stewart; Eleanor Wheeler; Sara M Willems; Claire Adams; Hanieh Yaghootkar; Nita G Forouhi; Kay-Tee Khaw; Andrew D Johnson; Robert K Semple; Timothy Frayling; John R B Perry; Emmanouil Dermitzakis; Mark I McCarthy; Inês Barroso; Nicholas J Wareham; David B Savage; Claudia Langenberg; Stephen O'Rahilly; Robert A Scott
Journal:  Nat Genet       Date:  2016-11-14       Impact factor: 38.330

7.  Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.

Authors:  Ying Wu; K Alaine Broadaway; Chelsea K Raulerson; Laura J Scott; Calvin Pan; Arthur Ko; Aiqing He; Charles Tilford; Christian Fuchsberger; Adam E Locke; Heather M Stringham; Anne U Jackson; Narisu Narisu; Johanna Kuusisto; Päivi Pajukanta; Francis S Collins; Michael Boehnke; Markku Laakso; Aldons J Lusis; Mete Civelek; Karen L Mohlke
Journal:  Hum Mol Genet       Date:  2019-12-15       Impact factor: 5.121

8.  Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis.

Authors:  Rona J Strawbridge; Helmut Laumen; Anders Hamsten; Michaela Breier; Harald Grallert; Hans Hauner; Peter Arner; Ingrid Dahlman
Journal:  PLoS One       Date:  2016-04-22       Impact factor: 3.240

9.  Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions.

Authors:  Margaret R Davis; Erik Arner; Cairnan R E Duffy; Paul A De Sousa; Ingrid Dahlman; Peter Arner; Kim M Summers
Journal:  Mol Genet Metab       Date:  2016-06-23       Impact factor: 4.797

10.  Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.

Authors:  Lucia Bialesova; Agné Kulyté; Paul Petrus; Indranil Sinha; Jurga Laurencikiene; Chunyan Zhao; Karin Dahlman Wright; Peter Arner; Ingrid Dahlman
Journal:  Sci Rep       Date:  2017-08-31       Impact factor: 4.379
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