Literature DB >> 26797318

Caregiver Satisfaction with a Multisite Trial of Atomoxetine and Parent Training for Attention-Deficit/Hyperactivity Disorder and Behavioral Noncompliance in Children with Autism Spectrum Disorder.

Jill A Hollway1, Michael G Aman1, Marissa I Mendoza-Burcham2, Laura Silverman3, L Eugene Arnold1, Rameshwari Tumuluru2, Benjamin L Handen2, Luc Lecavalier1, Kristin Page1, Pamela Sayre1, Tristram Smith3.   

Abstract

OBJECTIVE: The purpose of this study was to examine caregiver satisfaction with the research experience in a randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention-deficit/hyperactivity disorder (ADHD) and behavioral noncompliance co-occurring with autism.
METHODS: The Children with Hyperactivity and Autism Research Treatment Study (CHARTS) randomly assigned 128 children 5.00-14.11 years of age to four treatment groups (ATX + PT, ATX alone, PT + placebo[PBO], and PBO). Caregivers completed an 18 item questionnaire about their satisfaction with the research experience. We summarized caregiver responses with descriptive statistics and examined whether the responses were associated with demographic variables, treatment assignment, or the child's response to treatment (positive or negative).
RESULTS: Ninety-three percent of caregivers (119) completed the questionnaire. When asked if they would join the study again if given the chance, 87% (103) responded "yes," 13% (15) responded "maybe," and 1% (1) responded "no." When asked if they would recommend the study to other caregivers of children with similar problems, 92% (109) responded "yes" and 8% responded (10) "maybe." Of the 59 Parent Satisfaction Questionnaire (PSQ) respondents who received PT, 75% (44) felt more confident in managing current child behaviors, 24% (14) felt that their level of confidence was unchanged, and 2% (1) felt less confident. Most caregivers expressed satisfaction with the study procedures, including the number of visits and the safety monitoring protocols.
CONCLUSIONS: In general, caregivers were highly satisfied with their research experience. These findings may be useful for informing human subject committees and for designing study protocols that are appealing to families.

Entities:  

Keywords:  atomoxetine; autism spectrum disorder; parent training; satisfaction

Mesh:

Substances:

Year:  2016        PMID: 26797318      PMCID: PMC5116688          DOI: 10.1089/cap.2015.0130

Source DB:  PubMed          Journal:  J Child Adolesc Psychopharmacol        ISSN: 1044-5463            Impact factor:   2.576


  14 in total

1.  Assessing social validity in clinical treatment research: issues and procedures.

Authors:  S L Foster; E J Mash
Journal:  J Consult Clin Psychol       Date:  1999-06

2.  Atomoxetine, Parent Training, and Their Combination in Children With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.

Authors:  Benjamin L Handen; Michael G Aman; L Eugene Arnold; Susan L Hyman; Rameshwari V Tumuluru; Luc Lecavalier; Patricia Corbett-Dick; Xueliang Pan; Jill A Hollway; Kristin A Buchan-Page; Laura B Silverman; Nicole V Brown; Robert R Rice; Jessica Hellings; Daniel W Mruzek; Sarah McAuliffe-Bellin; Elizabeth A Hurt; Melissa M Ryan; Lynne Levato; Tristram Smith
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2015-09-03       Impact factor: 8.829

3.  A national sample of preschoolers with autism spectrum disorders: special education services and parent satisfaction.

Authors:  Amy Bitterman; Tamara C Daley; Sunil Misra; Elaine Carlson; Joy Markowitz
Journal:  J Autism Dev Disord       Date:  2008-01-29

4.  Consumer satisfaction with involvement in drug research: a social validity study.

Authors:  M G Aman; P L Wolford
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  1995-07       Impact factor: 8.829

5.  The Home Situations Questionnaire-PDD version: factor structure and psychometric properties.

Authors:  M Chowdhury; M G Aman; L Scahill; N Swiezy; L E Arnold; L Lecavalier; C Johnson; B Handen; K Stigler; K Bearss; D Sukhodolsky; C J McDougle
Journal:  J Intellect Disabil Res       Date:  2010-03

6.  Social validation of evidence-based practices in autism by parents, teachers, and administrators.

Authors:  Kevin Callahan; Robin K Henson; Angela K Cowan
Journal:  J Autism Dev Disord       Date:  2007-10-09

7.  Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.

Authors:  C Lord; M Rutter; A Le Couteur
Journal:  J Autism Dev Disord       Date:  1994-10

8.  Parent and teacher SNAP-IV ratings of attention deficit hyperactivity disorder symptoms: psychometric properties and normative ratings from a school district sample.

Authors:  Regina Bussing; Melanie Fernandez; Michelle Harwood; Cynthia Wilson Garvan; Sheila M Eyberg; James M Swanson
Journal:  Assessment       Date:  2008-02-29

9.  A Multisite Trial of Atomoxetine and Parent Training in Children with Autism Spectrum Disorders: Rationale and Design Challenges.

Authors:  Laura Silverman; Jill A Hollway; Tristram Smith; Michael G Aman; L Eugene Arnold; Xueliang Pan; Xiaobai Li; Benjamin L Handen
Journal:  Res Autism Spectr Disord       Date:  2014-07-01

10.  Effects of risperidone on aberrant behavior in persons with developmental disabilities: II. Social validity measures.

Authors:  David B McAdam; Jennifer R Zarcone; Jessica Hellings; Deborah A Napolitano; Stephen R Schroeder
Journal:  Am J Ment Retard       Date:  2002-07
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  3 in total

1.  Adverse Events of Atomoxetine in a Double-Blind Placebo-Controlled Study in Children with Autism.

Authors:  Rameshwari V Tumuluru; Patricia Corbett-Dick; Michael G Aman; Tristram Smith; L Eugene Arnold; Xueliang Pan; Kristin A Buchan-Page; Nicole V Brown; Melissa M Ryan; Susan L Hyman; Jessica Hellings; Craig Williams; Jill A Hollway; Luc Lecavalier; Robert R Rice; Sarah McAuliffe-Bellin; Benjamin L Handen
Journal:  J Child Adolesc Psychopharmacol       Date:  2017-05-16       Impact factor: 2.576

2.  Atomoxetine, Parent Training, and Their Effects on Sleep in Youth with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.

Authors:  Jill A Hollway; Marrisa Mendoza-Burcham; Rebecca Andridge; Michael G Aman; Benjamin Handen; L Eugene Arnold; Luc Lecavalier; Craig Williams; Laura Silverman; Tristram Smith
Journal:  J Child Adolesc Psychopharmacol       Date:  2017-11-07       Impact factor: 2.576

3.  The Effect of Myricetin on Pharmacokinetics of Atomoxetine and its Metabolite 4-Hydroxyatomoxetine In Vivo and In Vitro.

Authors:  Tian Lan; Xiao-Xia Hu; Bing-Qing Liang; Wen-He Pan; Quan Zhou; Ling-Jing Yuan; Guo-Xin Hu
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-04       Impact factor: 2.441

  3 in total

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