BACKGROUND: The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. OBJECTIVES: This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. METHODS: This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between children with asthma and controls. In addition, the association of serum IL-33 with asthma severity was investigated. RESULTS: The level of serum IL-33 was significantly higher in children with asthma than in controls (15.17 ± 32.3 vs. 0.61 ± 2.16 pg/ml; p = 0.028). It was significantly increased proportionately to asthma severity, namely 9.92 ± 30.26 pg/ml in children with mild asthma, 13.68 ± 29.27 pg/ml in children with moderate asthma and 31.92 ± 41.45 pg/ml in children with severe asthma (p = 0.026). CONCLUSION: Serum IL-33 is increased in children with asthma and is associated with disease severity.
BACKGROUND: The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. OBJECTIVES: This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. METHODS: This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between children with asthma and controls. In addition, the association of serum IL-33 with asthma severity was investigated. RESULTS: The level of serum IL-33 was significantly higher in children with asthma than in controls (15.17 ± 32.3 vs. 0.61 ± 2.16 pg/ml; p = 0.028). It was significantly increased proportionately to asthma severity, namely 9.92 ± 30.26 pg/ml in children with mild asthma, 13.68 ± 29.27 pg/ml in children with moderate asthma and 31.92 ± 41.45 pg/ml in children with severe asthma (p = 0.026). CONCLUSION: Serum IL-33 is increased in children with asthma and is associated with disease severity.
Authors: Oyebola O Oyesola; Carolina Duque; Linda C Huang; Elisabeth M Larson; Simon P Früh; Lauren M Webb; Seth A Peng; Elia D Tait Wojno Journal: J Immunol Date: 2020-01-03 Impact factor: 5.422
Authors: Matthew T Stier; Jian Zhang; Kasia Goleniewska; Jacqueline Y Cephus; Mark Rusznak; Lan Wu; Luc Van Kaer; Baohua Zhou; Dawn C Newcomb; R Stokes Peebles Journal: J Exp Med Date: 2017-12-08 Impact factor: 14.307
Authors: Alfredo Perales-Puchalt; Nikolaos Svoronos; Daniel O Villarreal; Urvi Zankharia; Emma Reuschel; Krzysztof Wojtak; Kyle K Payne; Elizabeth K Duperret; Kar Muthumani; Jose R Conejo-Garcia; David B Weiner Journal: Oncoimmunology Date: 2018-09-06 Impact factor: 8.110