Min Kyong Kim1, Chong Wha Baek2, Hyun Kang1, Geun Joo Choi1, Yong Hee Park1, So Young Yang1, Hwa Yong Shin1, Yong Hun Jung1, Young Cheol Woo1. 1. Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 156-755, Republic of Korea. 2. Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 156-755, Republic of Korea. Electronic address: nbjhwa@naver.com.
Abstract
STUDY OBJECTIVE: To compare recovery times and respiratory complications during emergence after deep extubation using either desflurane alone or a lower concentration of desflurane with remifentanil. DESIGN: Prospective randomized double-blind clinical trial. SETTING: Intraoperative. PATIENTS: A total of 62 patients between the ages of 20 and 60 years with American Society of Anesthesiologists class I or II and who underwent low- to intermediate-risk surgery of 2- to 4-hour duration were enrolled. INTERVENTIONS: Randomly assigned either 1.5 minimum alveolar concentration desflurane (group D; n = 31) or 1.0 minimum alveolar concentration of desflurane and 1.0 ng/mL effect-site concentration of remifentanil (group DR; n = 31). MEASUREMENTS: Recovery times, from the time of extubation to the time when the patients could breathe without assistance, were awake enough to maintain the airway independently, and exited the recovery room, as well as respiratory complications were compared between the groups. MAIN RESULTS:Recovery times were significantly reduced in the group DR (P < .001). The incidence of respiratory complications was also lower in group DR than in group D (48% vs 3.8%; P < .001). CONCLUSIONS: The combined use of remifentanil while lowering the concentration of desflurane improves recovery profiles during emergence after deep extubation.
RCT Entities:
STUDY OBJECTIVE: To compare recovery times and respiratory complications during emergence after deep extubation using either desflurane alone or a lower concentration of desflurane with remifentanil. DESIGN: Prospective randomized double-blind clinical trial. SETTING: Intraoperative. PATIENTS: A total of 62 patients between the ages of 20 and 60 years with American Society of Anesthesiologists class I or II and who underwent low- to intermediate-risk surgery of 2- to 4-hour duration were enrolled. INTERVENTIONS: Randomly assigned either 1.5 minimum alveolar concentration desflurane (group D; n = 31) or 1.0 minimum alveolar concentration of desflurane and 1.0 ng/mL effect-site concentration of remifentanil (group DR; n = 31). MEASUREMENTS: Recovery times, from the time of extubation to the time when the patients could breathe without assistance, were awake enough to maintain the airway independently, and exited the recovery room, as well as respiratory complications were compared between the groups. MAIN RESULTS: Recovery times were significantly reduced in the group DR (P < .001). The incidence of respiratory complications was also lower in group DR than in group D (48% vs 3.8%; P < .001). CONCLUSIONS: The combined use of remifentanil while lowering the concentration of desflurane improves recovery profiles during emergence after deep extubation.
Authors: Jin Qiu; Mian Xie; Jie Chen; Bing Chen; Yuanjing Chen; Xiwen Zhu; Hui Lin; Tao Zhu; Guangyou Duan; He Huang Journal: Front Med (Lausanne) Date: 2022-03-03
Authors: Jeremy Juang; Martha Cordoba; Alex Ciaramella; Mark Xiao; Jeremy Goldfarb; Jorge Enrique Bayter; Alvaro Andres Macias Journal: BMC Anesthesiol Date: 2020-10-29 Impact factor: 2.217