Natalia García-Casares1, Juan A García-Arnés2, Jose Rioja3, María José Ariza3, Antonio Gutiérrez4, Francisco Alfaro4, Alejandro Nabrozidis4, Pedro González-Alegre5, Pedro González-Santos3. 1. Department of Medicine, Faculty of Medicine, University of Malaga, Spain; Centro de Investigaciones Médico-Sanitarias (C.I.M.E.S.), University of Malaga, Spain. Electronic address: nagcasares@uma.es. 2. Department of Endocrinology, Carlos Haya Hospital, Malaga, Spain. 3. Department of Medicine, Faculty of Medicine, University of Malaga, Spain; Centro de Investigaciones Médico-Sanitarias (C.I.M.E.S.), University of Malaga, Spain. 4. Centro de Investigaciones Médico-Sanitarias (C.I.M.E.S.), University of Malaga, Spain. 5. Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
Abstract
AIM: To study the association between adiponectin plasma levels, and gray matter brain volume and cerebral glucose metabolism in a group of type 2 diabetes patients. METHODS: We studied 25 type 2 diabetes patients and 25 age- and gender-matched healthy control participants. Biochemical analysis and structural cerebral magnetic resonance imaging, including voxel-based morphometry and (18)-fluorodeoxyglucose positron emission tomography, were performed. The gray matter volumes and metabolism changes were analyzed using statistical parametric mapping (SPM8). RESULTS: Lower levels of adiponectin correlated with a lower gray matter volume in temporal regions and with reduced cerebral glucose metabolism in temporal regions (p<0.001), adjusted for age, gender, education, and the presence of at least one epsilon 4 allele for the apolipoprotein E (APOEε4 genotype). CONCLUSIONS: Positive correlations between adiponectin plasma levels and both gray matter volume and cerebral glucose metabolism were found, predominantly in temporal regions, as in Alzheimer's disease. Adiponectin might be a biomarker for the cognitive decline associated with type 2 diabetic patients.
AIM: To study the association between adiponectin plasma levels, and gray matter brain volume and cerebral glucose metabolism in a group of type 2 diabetespatients. METHODS: We studied 25 type 2 diabetespatients and 25 age- and gender-matched healthy control participants. Biochemical analysis and structural cerebral magnetic resonance imaging, including voxel-based morphometry and (18)-fluorodeoxyglucose positron emission tomography, were performed. The gray matter volumes and metabolism changes were analyzed using statistical parametric mapping (SPM8). RESULTS: Lower levels of adiponectin correlated with a lower gray matter volume in temporal regions and with reduced cerebral glucose metabolism in temporal regions (p<0.001), adjusted for age, gender, education, and the presence of at least one epsilon 4 allele for the apolipoprotein E (APOEε4 genotype). CONCLUSIONS: Positive correlations between adiponectin plasma levels and both gray matter volume and cerebral glucose metabolism were found, predominantly in temporal regions, as in Alzheimer's disease. Adiponectin might be a biomarker for the cognitive decline associated with type 2 diabeticpatients.
Authors: Natalia García-Casares; María R Bernal-López; Nuria Roé-Vellvé; Mario Gutiérrez-Bedmar; Jose C Fernández-García; Juan A García-Arnés; José R Ramos-Rodriguez; Francisco Alfaro; Sonia Santamaria-Fernández; Trevor Steward; Susana Jiménez-Murcia; Isabel Garcia-Garcia; Pedro Valdivielso; Fernando Fernández-Aranda; Francisco J Tinahones; Ricardo Gómez-Huelgas Journal: Nutrients Date: 2017-07-01 Impact factor: 5.717