M A Kazem1, A U Khan2, C R Selvasekar3. 1. Surgery and Cancer Division, Leighton Hospital, Middlewich Road, Crewe CW1 4QJ, UK. Electronic address: mhdalikazem@hotmail.com. 2. Surgery and Cancer Division, Leighton Hospital, Middlewich Road, Crewe CW1 4QJ, UK. 3. Department of Surgery, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.
Abstract
AIMS: To externally validate the MSKCC nomogram in a UK population, and determine if it could be used in our practice here in the UK. METHODS: The colon cancer database from a district general hospital in England was used to extract all patients who had a curative colon cancer resection. Inclusion criteria were all patients who had curative elective colon cancer resection between 01/01/1998 and 31/12/2003. Patients were followed up for up to ten years. Five and ten year predictions were calculated for each patient, and plotted against the actual recurrence using a ROC curve, and AUC was calculated for both the five and ten year nomogram. RESULTS: 138 patients were included in the study. Overall five year recurrence rate was 26.8% with a mean follow up of 60.24 months (SD = 38.6). 118 patients were included in the five year nomogram validation, and 102 patients were included in the ten year nomogram validation. A ROC curve was plotted for both the five and ten year nomogram and AUC was calculated. For the five year nomogram AUC was 0.673, and for the ten year nomogram AUC was 0.687. Two cut off points were identified for each nomogram and this divided the cohort into low, medium and high risk groups for recurrence. Cox regression showed there was significant difference between all groups for both nomograms. CONCLUSION: The MSKCC colon cancer nomogram was validated in our cohort, but it is recommended to be used in conjunction with AJCC TNM staging system.
AIMS: To externally validate the MSKCC nomogram in a UK population, and determine if it could be used in our practice here in the UK. METHODS: The colon cancer database from a district general hospital in England was used to extract all patients who had a curative colon cancer resection. Inclusion criteria were all patients who had curative elective colon cancer resection between 01/01/1998 and 31/12/2003. Patients were followed up for up to ten years. Five and ten year predictions were calculated for each patient, and plotted against the actual recurrence using a ROC curve, and AUC was calculated for both the five and ten year nomogram. RESULTS: 138 patients were included in the study. Overall five year recurrence rate was 26.8% with a mean follow up of 60.24 months (SD = 38.6). 118 patients were included in the five year nomogram validation, and 102 patients were included in the ten year nomogram validation. A ROC curve was plotted for both the five and ten year nomogram and AUC was calculated. For the five year nomogram AUC was 0.673, and for the ten year nomogram AUC was 0.687. Two cut off points were identified for each nomogram and this divided the cohort into low, medium and high risk groups for recurrence. Cox regression showed there was significant difference between all groups for both nomograms. CONCLUSION: The MSKCC colon cancer nomogram was validated in our cohort, but it is recommended to be used in conjunction with AJCC TNM staging system.
Authors: Martin R Weiser; Meier Hsu; Philip S Bauer; William C Chapman; Iván A González; Deyali Chatterjee; Deepak Lingam; Matthew G Mutch; Ajaratu Keshinro; Jinru Shia; Efsevia Vakiani; Tsuyoshi Konishi; Yoshifumi Shimada; Zsofia Stadler; Neil H Segal; Andrea Cercek; Leonard Saltz; Rona Yaeger; Anna Varghese; Maria Widmar; Iris H Wei; Emmanouil P Pappou; J Joshua Smith; Garrett Nash; Philip Paty; Julio Garcia-Aguilar; Mithat Gonen Journal: J Clin Oncol Date: 2021-01-13 Impact factor: 44.544
Authors: Tsuyoshi Konishi; Yoshifumi Shimada; Meier Hsu; Iris H Wei; Emmanouil Pappou; J Joshua Smith; Garrett M Nash; José G Guillem; Philip B Paty; Julio Garcia-Aguilar; Andrea Cercek; Rona Yaeger; Zsofia K Stadler; Neil H Segal; Anna Varghese; Leonard B Saltz; Jinru Shia; Efsevia Vakiani; Mithat Gönen; Martin R Weiser Journal: JNCI Cancer Spectr Date: 2019-04-25