Literature DB >> 2679636

The role of CD4 in T-cell activation: accessory molecule or co-receptor?

C A Janeway.   

Abstract

CD4 is an MHC class II binding protein found on T cells that recognize peptide fragments of protein antigens bound to MHC class II molecules. In this review, Charlie Janeway argues that CD4 is a physical component of the T-cell receptor, and that CD4 augments signalling via the receptor by about 100-fold. He proposes the term co-receptor to describe this molecule and its functional homologue, CD8.

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Year:  1989        PMID： 2679636     DOI： 10.1016/0167-5699(89)90260-0

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  28 in total

Review 1.  Role of major histocompatibility complex class-I molecules in tumor rejection. New insights from studies with synthetic peptides and transgenic mice.

Authors:  P Höglund; H G Ljunggren; K Kärre; G Jay
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

2.  Relative activities of distinct isotypes of murine and human major histocompatibility complex class II molecules in binding toxic shock syndrome toxin 1 and determination of CD antigens expressed on T cells generated upon stimulation by the toxin.

Authors:  T Uchiyama; S Saito; H Inoko; X J Yan; K Imanishi; M Araake; H Igarashi
Journal:  Infect Immun       Date:  1990-12       Impact factor: 3.441

3.  Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human immunodeficiency virus envelope glycoprotein gp120 and HLA class II antigens similarly.

Authors:  D Piatier-Tonneau; L N Gastinel; G Moussy; B Bénichou; F Amblard; P Vaigot; C Auffray
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

4.  Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

Authors:  S Sawada; D R Littman
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

Review 5.  The c-src family of protein-tyrosine kinases.

Authors:  P M Brickell
Journal:  Int J Exp Pathol       Date:  1991-02       Impact factor: 1.925

6.  Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy.

Authors:  Roger S Riley; David Williams; Micaela Ross; Shawn Zhao; Alden Chesney; Bradly D Clark; Jonathan M Ben-Ezra
Journal:  J Clin Lab Anal       Date:  2009       Impact factor: 2.352

7.  Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.

Authors:  R S Yeung; J M Penninger; T M Kündig; Y Law; K Yamamoto; N Kamikawaji; L Burkly; T Sasazuki; R Flavell; P S Ohashi; T W Mak
Journal:  J Exp Med       Date:  1994-11-01       Impact factor: 14.307

8.  Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule.

Authors:  P Bérubé; B Barbeau; R Cantin; R P Sékaly; M Tremblay
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

9.  B cells control the aggregability of CD4 on T cells through continuous physical interactions.

Authors:  S Mecheri; G Dannecker; D Dennig; M K Hoffmann
Journal:  Immunology       Date:  1991-12       Impact factor: 7.397

10.  Analysis of the basis of resistance and susceptibility of CD4+ T cells to human immunodeficiency virus (HIV)-gp120 induced anergy.

Authors:  A Faith; R E O'Hehir; M Malkovsky; J R Lamb
Journal:  Immunology       Date:  1992-06       Impact factor: 7.397
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