| Literature DB >> 26796272 |
Fatemeh Pourgholi1, Mahsa Hajivalili1, Jadidi-Niaragh Farhad2, Hossein Samadi Kafil3, Mehdi Yousefi4.
Abstract
Glioblastoma multiform (GBM) is the most common brain tumor. The current GBM treatments comprise of radiation therapy, chemotherapy and surgery. One of the most important problems regarding the treatment of GBM is the presence of blood brain barrier (BBB) which inhibits the efficient drug delivery into central nervous system (CNS). Nanothechnology can help to deliver therapeutic drugs into CNS through crossing the BBB. There are different types of nanoparticles (Nps) which can be manipulated for clinical applications as a treatment for CNS-related disorders. In this review, we will discuss the role of Nps in the treatment of GBM.Entities:
Keywords: Drug delivery; Glioblastoma; Nanoparticle; Treatment
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Year: 2015 PMID: 26796272 DOI: 10.1016/j.biopha.2015.12.014
Source DB: PubMed Journal: Biomed Pharmacother ISSN: 0753-3322 Impact factor: 6.529