Literature DB >> 26795636

Post-translational Modifications in Heart Failure: Small Changes, Big Impact.

Ahyoung Lee1, Jae Gyun Oh1, Przemek A Gorski1, Roger J Hajjar1, Changwon Kho2.   

Abstract

Heart failure is a complex disease process with various aetiologies and is a significant cause of morbidity and death world-wide. Post-translational modifications (PTMs) alter protein structure and provide functional diversity in terms of physiological functions of the heart. In addition, alterations in protein PTMs have been implicated in human disease pathogenesis. Small ubiquitin-like modifier mediated modification (SUMOylation) pathway was found to play essential roles in cardiac development and function. Abnormal SUMOylation has emerged as a new feature of heart failure pathology. In this review, we will highlight the importance of SUMOylation as a regulatory mechanism of SERCA2a function, and its therapeutic potential for the treatment of heart failure.
Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Heart failure; Post-translational modifications; SERCA2a; SUMO

Mesh：

Substances：

Year:  2015        PMID： 26795636      PMCID： PMC4775300          DOI： 10.1016/j.hlc.2015.11.008

Source DB:  PubMed          Journal:  Heart Lung Circ        ISSN： 1443-9506            Impact factor:   2.975


  74 in total

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2.  SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy.

Authors:  Eun Young Kim; Yi Zhang; Ilimbek Beketaev; Ana Maria Segura; Wei Yu; Yutao Xi; Jiang Chang; Jun Wang
Journal:  J Mol Cell Cardiol       Date:  2014-08-12       Impact factor: 5.000

3.  Defective sumoylation pathway directs congenital heart disease.

Authors:  Jun Wang; Li Chen; Shu Wen; Huiping Zhu; Wei Yu; Ivan P Moskowitz; Gary M Shaw; Richard H Finnell; Robert J Schwartz
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2011-05-11

4.  Involvement of activated SUMO-2 conjugation in cardiomyopathy.

Authors:  Eun Young Kim; Yi Zhang; Bo Ye; Ana Maria Segura; Ilimbek Beketaev; Yutao Xi; Wei Yu; Jiang Chang; Faqian Li; Jun Wang
Journal:  Biochim Biophys Acta       Date:  2015-04-06

5.  Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.

Authors:  L Gong; B Li; S Millas; E T Yeh
Journal:  FEBS Lett       Date:  1999-04-01       Impact factor: 4.124

6.  The nucleoporin RanBP2 has SUMO1 E3 ligase activity.

Authors:  Andrea Pichler; Andreas Gast; Jacob S Seeler; Anne Dejean; Frauke Melchior
Journal:  Cell       Date:  2002-01-11       Impact factor: 41.582

Review 7.  FGF signalling and SUMO modification: new players in the aetiology of cleft lip and/or palate.

Authors:  Erwin Pauws; Philip Stanier
Journal:  Trends Genet       Date:  2007-11-05       Impact factor: 11.639

Review 8.  Sumoylation in neurodegenerative diseases.

Authors:  Petranka Krumova; Jochen H Weishaupt
Journal:  Cell Mol Life Sci       Date:  2012-09-25       Impact factor: 9.261

9.  Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies.

Authors:  Yu-Qian Zhang; Kevin D Sarge
Journal:  J Cell Biol       Date:  2008-07-07       Impact factor: 10.539

Review 10.  SERCA2a: a prime target for modulation of cardiac contractility during heart failure.

Authors:  Woo Jin Park; Jae Gyun Oh
Journal:  BMB Rep       Date:  2013-05       Impact factor: 4.778
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  7 in total

Review 1.  Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve.

Authors:  Peggi M Angel; H Scott Baldwin; Danielle Gottlieb Sen; Yan Ru Su; John E Mayer; David Bichell; Richard R Drake
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2017-03-21       Impact factor: 3.036

2.  Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.

Authors:  Hadi R Ali; Cole R Michel; Ying H Lin; Timothy A McKinsey; Mark Y Jeong; Amrut V Ambardekar; Joseph C Cleveland; Richard Reisdorph; Nichole Reisdorph; Kathleen C Woulfe; Kristofer S Fritz
Journal:  J Mol Cell Cardiol       Date:  2019-12-10       Impact factor: 5.000

3.  Cross-communication between fibroblasts and cardiomyocytes.

Authors:  Jae Gyun Oh; Changwon Kho
Journal:  Noncoding RNA Investig       Date:  2019-03-18

Review 4.  Cardiac small-conductance calcium-activated potassium channels in health and disease.

Authors:  Xiao-Dong Zhang; Phung N Thai; Deborah K Lieu; Nipavan Chiamvimonvat
Journal:  Pflugers Arch       Date:  2021-02-23       Impact factor: 3.657

Review 5.  Systems biology: An emerging strategy for discovering novel pathogenetic mechanisms that promote cardiovascular disease.

Authors:  Bradley A Maron; Jane A Leopold
Journal:  Glob Cardiol Sci Pract       Date:  2016-09-30

Review 6.  The role of post-translational modifications in cardiac hypertrophy.

Authors:  Kaowen Yan; Kun Wang; Peifeng Li
Journal:  J Cell Mol Med       Date:  2019-04-04       Impact factor: 5.310

Review 7.  Deciphering the SUMO code in the kidney.

Authors:  Zhen Yang; Yuming Zhang; Shiren Sun
Journal:  J Cell Mol Med       Date:  2018-12-01       Impact factor: 5.310
  7 in total

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