Literature DB >> 26795215

[Delirium and delirium management in critically ill patients].

A Kersten1, S Reith2.   

Abstract

Delirium in critically ill patients is a common entity in the intensive care unit (ICU) and is an expression of the cerebral organ dysfunction of the patient. The hallmark signs are disturbed consciousness and cognition in combination with inattentiveness and alterations in perception, which are manifested within a time interval of hours to days during treatment on the ICU. Delirium has been shown to have negative effects on patient short-term and long-term outcome parameters and increases morbidity and mortality. Despite its significance in many cases delirium remains inadequately diagnosed during routine treatment by ICU personnel. There are two validated and easily applicable scales for the standardized diagnosis of delirium: the confusion assessment method for the ICU (CAM-ICU) and the intensive care delirium screening checklist (ICDSC). These are simple to apply by medical as well as non-medical personnel. The therapy of delirium is mostly determined by non-pharmacological measures aiming at early identification, reorientation and mobilization of the patient, improving cerebral activity and establishing adequate wake-sleep cycles. There is only sparse evidence for pharmacological treatment of delirium; however, the choice of sedative agent has a proven effect on the incidence and duration of delirium in the ICU.

Entities:  

Keywords:  Dexmedetomidine; Haloperidol; Mobilization; Orientation; Sedation

Mesh:

Substances:

Year:  2016        PMID: 26795215     DOI: 10.1007/s00063-015-0130-z

Source DB:  PubMed          Journal:  Med Klin Intensivmed Notfmed        ISSN: 2193-6218            Impact factor:   0.840


  43 in total

Review 1.  Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm.

Authors:  Eduard E Vasilevskis; E Wesley Ely; Theodore Speroff; Brenda T Pun; Leanne Boehm; Robert S Dittus
Journal:  Chest       Date:  2010-11       Impact factor: 9.410

2.  Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients.

Authors:  Yahya Shehabi; Richard R Riker; Paula M Bokesch; Wayne Wisemandle; Ayumi Shintani; E Wesley Ely
Journal:  Crit Care Med       Date:  2010-12       Impact factor: 7.598

3.  Dissemination of the hospital elder life program: implementation, adaptation, and successes.

Authors:  Sharon K Inouye; Dorothy I Baker; Patricia Fugal; Elizabeth H Bradley
Journal:  J Am Geriatr Soc       Date:  2006-10       Impact factor: 5.562

4.  Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.

Authors:  William D Schweickert; Mark C Pohlman; Anne S Pohlman; Celerina Nigos; Amy J Pawlik; Cheryl L Esbrook; Linda Spears; Megan Miller; Mietka Franczyk; Deanna Deprizio; Gregory A Schmidt; Amy Bowman; Rhonda Barr; Kathryn E McCallister; Jesse B Hall; John P Kress
Journal:  Lancet       Date:  2009-05-14       Impact factor: 79.321

5.  Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial.

Authors:  Richard R Riker; Yahya Shehabi; Paula M Bokesch; Daniel Ceraso; Wayne Wisemandle; Firas Koura; Patrick Whitten; Benjamin D Margolis; Daniel W Byrne; E Wesley Ely; Marcelo G Rocha
Journal:  JAMA       Date:  2009-02-02       Impact factor: 56.272

6.  Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.

Authors:  Pratik P Pandharipande; Brenda T Pun; Daniel L Herr; Mervyn Maze; Timothy D Girard; Russell R Miller; Ayumi K Shintani; Jennifer L Thompson; James C Jackson; Stephen A Deppen; Renee A Stiles; Robert S Dittus; Gordon R Bernard; E Wesley Ely
Journal:  JAMA       Date:  2007-12-12       Impact factor: 56.272

7.  An intervention integrated into daily clinical practice reduces the incidence of delirium during hospitalization in elderly patients.

Authors:  María T Vidán; Elisabet Sánchez; Mar Alonso; Beatriz Montero; Javier Ortiz; José A Serra
Journal:  J Am Geriatr Soc       Date:  2009-09-15       Impact factor: 5.562

8.  Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial.

Authors:  Timothy D Girard; John P Kress; Barry D Fuchs; Jason W W Thomason; William D Schweickert; Brenda T Pun; Darren B Taichman; Jan G Dunn; Anne S Pohlman; Paul A Kinniry; James C Jackson; Angelo E Canonico; Richard W Light; Ayumi K Shintani; Jennifer L Thompson; Sharon M Gordon; Jesse B Hall; Robert S Dittus; Gordon R Bernard; E Wesley Ely
Journal:  Lancet       Date:  2008-01-12       Impact factor: 79.321

Review 9.  Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit.

Authors:  Juliana Barr; Gilles L Fraser; Kathleen Puntillo; E Wesley Ely; Céline Gélinas; Joseph F Dasta; Judy E Davidson; John W Devlin; John P Kress; Aaron M Joffe; Douglas B Coursin; Daniel L Herr; Avery Tung; Bryce R H Robinson; Dorrie K Fontaine; Michael A Ramsay; Richard R Riker; Curtis N Sessler; Brenda Pun; Yoanna Skrobik; Roman Jaeschke
Journal:  Crit Care Med       Date:  2013-01       Impact factor: 7.598

10.  Days of delirium are associated with 1-year mortality in an older intensive care unit population.

Authors:  Margaret A Pisani; So Yeon Joyce Kong; Stanislav V Kasl; Terrence E Murphy; Katy L B Araujo; Peter H Van Ness
Journal:  Am J Respir Crit Care Med       Date:  2009-09-10       Impact factor: 21.405

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