Literature DB >> 26794870

Structural insights of mTOR complex 1.

Hai-Xin Yuan1, Kun-Liang Guan2.   

Abstract

The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights into the regulation and substrate selectivity of mTORC1.

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Year:  2016        PMID： 26794870      PMCID： PMC4783463          DOI： 10.1038/cr.2016.10

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  6 in total

Review 1.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

Review 2.  Rapamycin passes the torch: a new generation of mTOR inhibitors.

Authors:  Don Benjamin; Marco Colombi; Christoph Moroni; Michael N Hall
Journal:  Nat Rev Drug Discov       Date:  2011-10-31       Impact factor: 84.694

3.  Architecture of human mTOR complex 1.

Authors:  Christopher H S Aylett; Evelyn Sauer; Stefan Imseng; Daniel Boehringer; Michael N Hall; Nenad Ban; Timm Maier
Journal:  Science       Date:  2015-12-17       Impact factor: 47.728

Review 4.  Molecular mechanisms of mTOR-mediated translational control.

Authors:  Xiaoju Max Ma; John Blenis
Journal:  Nat Rev Mol Cell Biol       Date:  2009-04-02       Impact factor: 94.444

5.  Structure of the human mTOR complex I and its implications for rapamycin inhibition.

Authors:  Calvin K Yip; Kazuyoshi Murata; Thomas Walz; David M Sabatini; Seong A Kang
Journal:  Mol Cell       Date:  2010-06-11       Impact factor: 17.970

6.  mTOR kinase structure, mechanism and regulation.

Authors:  Haijuan Yang; Derek G Rudge; Joseph D Koos; Bhamini Vaidialingam; Hyo J Yang; Nikola P Pavletich
Journal:  Nature       Date:  2013-05-01       Impact factor: 49.962
  6 in total
  10 in total

Review 1.  Mechanistic target of rapamycin inhibitors: successes and challenges as cancer therapeutics.

Authors:  Muireann Ní Bhaoighill; Elaine A Dunlop
Journal:  Cancer Drug Resist       Date:  2019-12-19

Review 2.  Antioxidants in Sport Sarcopenia.

Authors:  Maria Michela Cesare; Francesca Felice; Veronica Santini; Rossella Di Stefano
Journal:  Nutrients       Date:  2020-09-19       Impact factor: 5.717

3.  Knockdown of anion exchanger 2 suppressed the growth of ovarian cancer cells via mTOR/p70S6K1 signaling.

Authors:  Li-Jun Zhang; Renquan Lu; Ya-Nan Song; Jian-Yong Zhu; Wei Xia; Miao Zhang; Zhi-Yi Shao; Yan Huang; Yuqi Zhou; Hongqin Zhang; Lin Guo; Meiqin Zhang; Hong Zhang
Journal:  Sci Rep       Date:  2017-07-25       Impact factor: 4.379

Review 4.  "mTOR Signaling Pathway": A Potential Target of Curcumin in the Treatment of Spinal Cord Injury.

Authors:  Jingquan Lin; Xue Huo; Xuehong Liu
Journal:  Biomed Res Int       Date:  2017-06-12       Impact factor: 3.411

Review 5.  mTOR inhibitors in cancer therapy.

Authors:  Jianling Xie; Xuemin Wang; Christopher G Proud
Journal:  F1000Res       Date:  2016-08-25

Review 6.  Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity.

Authors:  Seraina Faes; Nicolas Demartines; Olivier Dormond
Journal:  Oxid Med Cell Longev       Date:  2017-02-09       Impact factor: 6.543

7.  Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.

Authors:  Anaelle A Dumas; Nicola Pomella; Gabriel Rosser; Loredana Guglielmi; Claire Vinel; Thomas O Millner; Jeremy Rees; Natasha Aley; Denise Sheer; Jun Wei; Anantha Marisetty; Amy B Heimberger; Robert L Bowman; Sebastian Brandner; Johanna A Joyce; Silvia Marino
Journal:  EMBO J       Date:  2020-06-22       Impact factor: 11.598

Review 8.  mTOR Signaling Pathway in Cancer Targets Photodynamic Therapy In Vitro.

Authors:  Sandra M Ayuk; Heidi Abrahamse
Journal:  Cells       Date:  2019-05-09       Impact factor: 6.600

9.  Cross-Species Suppression of Hepatoma Cell Growth and Migration by a Schistosoma japonicum MicroRNA.

Authors:  Yu Lin; Shanli Zhu; Chao Hu; Jing Wang; Pengyue Jiang; Liufang Zhu; Zhengli Li; Sai Wang; Yuanbin Zhang; Xindong Xu; Weiqing Pan
Journal:  Mol Ther Nucleic Acids       Date:  2019-09-17       Impact factor: 8.886

10.  eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.

Authors:  Shijie Ma; Zizheng Dong; Yanfei Huang; Jing-Yuan Liu; Jian-Ting Zhang
Journal:  Oncogene       Date:  2022-03-12       Impact factor: 8.756
  10 in total

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