Eduardo Ottobelli Chielle1, Willian Marciel de Souza2, Thainan Paz da Silva3, Rafael Noal Moresco4, Maria Beatriz Moretto5. 1. Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil; Center Healthy Sciences, University of West of Santa Catarina, UNOESC, 89900-000 São Miguel do Oeste, SC, Brazil. 2. Center Healthy Sciences, University of West of Santa Catarina, UNOESC, 89900-000 São Miguel do Oeste, SC, Brazil. 3. Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil. 4. Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil; Center of Healthy Sciences, UFSM-Santa Maria-Brazil. 5. Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil; Center of Healthy Sciences, UFSM-Santa Maria-Brazil. Electronic address: beatriz@smail.ufsm.br.
Abstract
OBJECTIVE: The aim of the study was to assess the influence of overweight and obesity in youth on adipocytokines levels, inflammatory and oxidative markers. DESIGN AND METHODS: Cross-sectional study of 149 young adults (54 normal weight, 27 overweight, 68 obese).Clinical and biochemical parameters, including lipid profile, fasting glucose, insulin and HOMA were determined. The levels of adipocytokines(adiponectin, retinol-binding protein 4 (RBP4), and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP) adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) activities, serum IL-6 levels and oxidative stress (malondialdehyde and ferric reducing antioxidant power - FRAP) were measured. RESULTS: Obese subjects presented significantly lower levels of Sulfhydryl groups (SH groups), adiponectin, HDL-C and the highest levels of RBP4, hs-CRP, resistin, IL-6, ADA, DPP-IV activities, and oxidative markers than compared to those who were of normal weight. There was a positive correlation between hs-CRP, IL-6, DDP-IV activity, anthropometric measurements and biochemical parameters. CONCLUSIONS: This analysis shows that resistin, RBP4, IL-6, ADA and DPP-IV activities and the reduction of adiponectin can promote inflammation, impairment of insulin sensitivity, and may contribute development of the pathways involved in obesity. These findings may hold promise in identifying new inflammatory markers, benchmarks that assist in the diagnosis and monitoring of patients with overweight and obese.
OBJECTIVE: The aim of the study was to assess the influence of overweight and obesity in youth on adipocytokines levels, inflammatory and oxidative markers. DESIGN AND METHODS: Cross-sectional study of 149 young adults (54 normal weight, 27 overweight, 68 obese).Clinical and biochemical parameters, including lipid profile, fasting glucose, insulin and HOMA were determined. The levels of adipocytokines(adiponectin, retinol-binding protein 4 (RBP4), and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP) adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) activities, serum IL-6 levels and oxidative stress (malondialdehyde and ferric reducing antioxidant power - FRAP) were measured. RESULTS:Obese subjects presented significantly lower levels of Sulfhydryl groups (SH groups), adiponectin, HDL-C and the highest levels of RBP4, hs-CRP, resistin, IL-6, ADA, DPP-IV activities, and oxidative markers than compared to those who were of normal weight. There was a positive correlation between hs-CRP, IL-6, DDP-IV activity, anthropometric measurements and biochemical parameters. CONCLUSIONS: This analysis shows that resistin, RBP4, IL-6, ADA and DPP-IV activities and the reduction of adiponectin can promote inflammation, impairment of insulin sensitivity, and may contribute development of the pathways involved in obesity. These findings may hold promise in identifying new inflammatory markers, benchmarks that assist in the diagnosis and monitoring of patients with overweight and obese.
Authors: Elena Moretti; Lucia Micheli; Daria Noto; Anna Ida Fiaschi; Andrea Menchiari; Daniela Cerretani Journal: Oxid Med Cell Longev Date: 2019-10-22 Impact factor: 6.543
Authors: B Sanz; G Larrinaga; A Fernandez-Atucha; J Gil; A B Fraile-Bermudez; M Kortajarena; A Izagirre; P Martinez-Lage; J Irazusta Journal: Heliyon Date: 2018-05-14