| Literature DB >> 26794395 |
Dingkong Liang1, Si Shi1, Jin Xu1, Bo Zhang1, Yi Qin1, Shunrong Ji1, Wenyan Xu1, Jiang Liu1, Liang Liu1, Chen Liu1, Jiang Long1, Quanxing Ni1, Xianjun Yu2.
Abstract
Pancreatic cancer is one of the most malignant human tumors. Perineural invasion, whereby a cancer cell invades the perineural spaces surrounding nerves, is acknowledged as a gradual contributor to cancer aggressiveness. Furthermore, perineural invasion is considered one of the root causes of the recurrence and metastasis observed after pancreatic resection, and it is also an independent predictor of prognosis. Advanced research has demonstrated that the neural microenvironment is closely associated with perineural invasion in pancreatic cancer. Therapy targeting the molecular mechanism of perineural invasion may enable the durable clinical treatment of this formidable disease. This review provides an overview of the present status of perineural invasion, the relevant molecular mechanisms of perineural invasion, pain and hyperglycemia associated with perineural invasion in pancreatic cancer, and the targeted therapeutics based on these studies.Entities:
Keywords: Cancer microenvironment; Pancreatic cancer; Perineural invasion; Prognostic factor
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Year: 2016 PMID： 26794395 DOI： 10.1016/j.bbcan.2016.01.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002