Fei-Shen Lin1, Mei-Ying Wu1, Wen-Jun Tu1, Hong-Qiu Pan1, Jian Zheng1, Jun-Wei Shi1, Zhong-Ting Fei1, Rui-Mei Zhang1, Wei-Guo Yan1, Ming-Qun Shang1, Qiang Zheng1, Meng-Jie Wang1, Xia Zhang1. 1. 1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Abstract
BACKGROUND: To investigate the prevalence of and risk factors for leukopenia in tuberculosis patients and the impact of anti-tuberculosis regimens on the occurrence of leukopenia in newly treated tuberculosis patients. METHODS: A total of 1,904 tuberculosis patients were included in the study. A cross-sectional survey of the prevalence of leukopenia was initially conducted, and then factors influencing leukopenia were identified using Logistic regression analysis. Non-treatment factors influencing peripheral blood leukocyte counts were analyzed using univariate COX proportional hazards models. Covariate analysis was used to assess the independent effect of different anti-tuberculosis regimens on peripheral blood leukocyte counts. RESULTS: Being female, advanced age and longer duration of previous anti-tuberculosis treatment (>6 month) were risk factors for leukopenia in tuberculosis patients, while secondary pulmonary tuberculosis, higher body mass index (BMI: 24-27.9 kg/m(2)), and higher degree of education (senior high school or above) were protective factors. Gender, vegetable consumption, drinking, pulmonary infection, other chronic diseases, and use of antibiotics were significantly associated with the development of leukopenia in patients on anti-tuberculosis treatment. In tuberculosis patients treated with anti-tuberculosis regimens not containing antibiotics, peripheral blood leukocyte levels gradually declined with the prolongation of treatment duration. In tuberculosis patients treated with anti-tuberculosis regimens containing antibiotics, peripheral blood leukocyte levels showed a declining trend. CONCLUSIONS: Female patients, patients at advanced age and recurrent tuberculosis patients having longer previous anti-tuberculosis treatment are high-risk populations for leukopenia. Attention should be paid to the influence of vegetable consumption and drinking, co-morbidities and use of antibiotics during anti-tuberculosis treatment.
BACKGROUND: To investigate the prevalence of and risk factors for leukopenia in tuberculosispatients and the impact of anti-tuberculosis regimens on the occurrence of leukopenia in newly treated tuberculosispatients. METHODS: A total of 1,904 tuberculosispatients were included in the study. A cross-sectional survey of the prevalence of leukopenia was initially conducted, and then factors influencing leukopenia were identified using Logistic regression analysis. Non-treatment factors influencing peripheral blood leukocyte counts were analyzed using univariate COX proportional hazards models. Covariate analysis was used to assess the independent effect of different anti-tuberculosis regimens on peripheral blood leukocyte counts. RESULTS: Being female, advanced age and longer duration of previous anti-tuberculosis treatment (>6 month) were risk factors for leukopenia in tuberculosispatients, while secondary pulmonary tuberculosis, higher body mass index (BMI: 24-27.9 kg/m(2)), and higher degree of education (senior high school or above) were protective factors. Gender, vegetable consumption, drinking, pulmonary infection, other chronic diseases, and use of antibiotics were significantly associated with the development of leukopenia in patients on anti-tuberculosis treatment. In tuberculosispatients treated with anti-tuberculosis regimens not containing antibiotics, peripheral blood leukocyte levels gradually declined with the prolongation of treatment duration. In tuberculosispatients treated with anti-tuberculosis regimens containing antibiotics, peripheral blood leukocyte levels showed a declining trend. CONCLUSIONS: Female patients, patients at advanced age and recurrent tuberculosispatients having longer previous anti-tuberculosis treatment are high-risk populations for leukopenia. Attention should be paid to the influence of vegetable consumption and drinking, co-morbidities and use of antibiotics during anti-tuberculosis treatment.
Authors: Erik C von Rosenvinge; Yang Song; James R White; Cynthia Maddox; Thomas Blanchard; W Florian Fricke Journal: ISME J Date: 2013-03-07 Impact factor: 10.302
Authors: P Cahn; K Ruxrungtham; B Gazzard; R S Diaz; A Gori; D P Kotler; A Vriesema; N A Georgiou; J Garssen; M Clerici; J M A Lange Journal: Clin Infect Dis Date: 2013-03-19 Impact factor: 9.079
Authors: K Kawai; S N Meydani; W Urassa; D Wu; F M Mugusi; E Saathoff; R J Bosch; E Villamor; D Spiegelman; W W Fawzi Journal: Epidemiol Infect Date: 2013-10-07 Impact factor: 4.434