Yong Il Hwang1, Sang Haak Lee1, Jee Hong Yoo1, Bock Hyun Jung1, Kwang Ha Yoo1, Moon Jun Na1, Jong Deog Lee1, Myung Jae Park1, Chi Young Jung1, Jae Jeong Shim1, Kyung Chan Kim1, Yeon Jae Kim1, Hye Sook Choi1, Ik Su Choi1, Choon-Taek Lee1, Sang Do Lee1, Do Jin Kim1, Soo-Taek Uh1, Ho Sung Lee1, Young Sam Kim1, Kwan Ho Lee1, Seung Won Ra1, Hak Ryul Kim1, Soo Jeon Choi1, In Won Park1, Yong Bum Park1, So Young Park1, Jaehee Lee1, Ki-Suck Jung1. 1. 1 Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea ; 2 St. Paul's Hospital, The Catholic University of Korea, Seoul, Korea ; 3 Kyung Hee University Hospital at Gangdong, Seoul, Korea ; 4 GangNeung Asan Hospital, Gangneung, Korea ; 5 Konkuk University Medical Center, Seoul, Korea ; 6 Konyang University Hospital, Daejeon, Korea ; 7 Gyeongsang National University Hospital, Jinju-si, Korea ; 8 Kyung Hee University Medical Center, Seoul, Korea ; 9 Keimyung University Dongsan Medical Center, Daegu, Korea ; 10 Korea University Guro Hospital, Seoul, Korea ; 11 Daegu Catholic University Medical Center, Daegu, Korea ; 12 Daegu Fatima Hospital, Daegu, Korea ; 13 Dongguk University Gyeongju Hospital, Gyeongju-si, Korea ; 14 Maryknoll Medical Center, Busan, Korea ; 15 Seoul National University Bundang Hospital, Seongnam, Korea ; 16 Asan Medical Center, Seoul, Korea ; 17 Soonchunhyang University Bucheon Hospital, Bucheon, Korea ; 18 Soonchunhyang University Seoul Hospital, Seoul, Korea ; 19 Soonchunhyang University Cheonan Hospital, Cheonan, Korea ; 20 Severance Hospital, Seoul, Korea ; 21 Yeungnam University Medical Center, Daegu, Korea ; 22 Ulsan University Hospital, Ulsan, Korea ; 23 Wonkwang University School of Medicine, Iksan, Korea ; 24 Inje University Sanggye Paik Hospital, Seoul, Korea ; 25 Chung-Ang University Hospital, Seoul, Korea ; 26 Hallym University Kangdong Sacred Heart Hospital, Anyang-si, Korea ; 27 Kyungpook National University Hospital, Daegu, Korea.
Abstract
BACKGROUND: In South Korea, chronic obstructive pulmonary disease (COPD) is one of the ten leading causes of death. COPD exacerbations are significantly associated with mortality in COPD patients. This study was conducted to investigate the epidemiology of COPD in South Korea, specifically the clinical characteristics of South Korean COPD patients, the COPD exacerbation rate and the risk factors associated with COPD exacerbations. METHODS: This study covers a 2-year interval. One year was data collected retrospectively and the second year was prospectively obtained data. RESULTS: A total of 1,114 subjects were enrolled in the study. These subjects were observed for a period of 1 year from the enrollment, and a total of 920 subjects completed the study. A total of 1,357 COPD exacerbations occurred in 711 subjects (63.8%) out of the total of 1,114 subjects during the study period of 2 years. Multivariate logistic regression results showed that if patients had had a pneumonia before the retrospective year of analysis, they had a 18 times greater chance of having an exacerbation during the prospective year when other variables were controlled. Also, the subjects who had a history of two or more exacerbations during the retrospective year were approximately 6 times more likely to experience the COPD exacerbation compared to those who did not. CONCLUSIONS: This study examined the demographic and clinical characteristics of South Korean COPD patients and found that a history of pneumonia and two or more occurrences of exacerbation within 1 year was significantly associated with a higher rate of COPD exacerbation.
BACKGROUND: In South Korea, chronic obstructive pulmonary disease (COPD) is one of the ten leading causes of death. COPD exacerbations are significantly associated with mortality in COPDpatients. This study was conducted to investigate the epidemiology of COPD in South Korea, specifically the clinical characteristics of South Korean COPDpatients, the COPD exacerbation rate and the risk factors associated with COPD exacerbations. METHODS: This study covers a 2-year interval. One year was data collected retrospectively and the second year was prospectively obtained data. RESULTS: A total of 1,114 subjects were enrolled in the study. These subjects were observed for a period of 1 year from the enrollment, and a total of 920 subjects completed the study. A total of 1,357 COPD exacerbations occurred in 711 subjects (63.8%) out of the total of 1,114 subjects during the study period of 2 years. Multivariate logistic regression results showed that if patients had had a pneumonia before the retrospective year of analysis, they had a 18 times greater chance of having an exacerbation during the prospective year when other variables were controlled. Also, the subjects who had a history of two or more exacerbations during the retrospective year were approximately 6 times more likely to experience the COPD exacerbation compared to those who did not. CONCLUSIONS: This study examined the demographic and clinical characteristics of South Korean COPDpatients and found that a history of pneumonia and two or more occurrences of exacerbation within 1 year was significantly associated with a higher rate of COPD exacerbation.
Authors: J J Soler-Cataluña; M A Martínez-García; P Román Sánchez; E Salcedo; M Navarro; R Ochando Journal: Thorax Date: 2005-07-29 Impact factor: 9.139
Authors: Berendina M Roede; Patrick Je Bindels; Henk J Brouwer; Paul Bresser; Corianne Ajm de Borgie; Jan M Prins Journal: Br J Gen Pract Date: 2006-09 Impact factor: 5.386
Authors: Maria Montes de Oca; Carlos Tálamo; Ronald J Halbert; Rogelio Perez-Padilla; Maria Victorina Lopez; Adriana Muiño; José Roberto B Jardim; Gonzalo Valdivia; Julio Pertuzé; Dolores Moreno; Ana Maria B Menezes Journal: Chest Date: 2009-04-06 Impact factor: 9.410
Authors: Simon van der Schans; Lucas M A Goossens; Melinde R S Boland; Janwillem W H Kocks; Maarten J Postma; Job F M van Boven; Maureen P M H Rutten-van Mölken Journal: Pharmacoeconomics Date: 2017-01 Impact factor: 4.981