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Literature DB >> 26792747

Dissecting the Molecular Mechanisms of the Tropism of Varicella-Zoster Virus for Human T Cells.

Abstract

Studies of varicella-zoster virus (VZV) tropism for T cells support their role in viral transport to the skin during primary infection. Multiparametric single-cell mass cytometry demonstrates that, instead of preferentially infecting skin-homing T cells, VZV alters cell signaling and remodels surface proteins to enhance T cell skin trafficking. Viral proteins dispensable in skin, such as that encoded by open reading frame 66, are necessary in T cells. Interference with VZV T cell tropism may offer novel strategies for drug and vaccine design.

Entities: Disease Species

Mesh：

Substances：
Herpes Zoster Vaccine

Year: 2016 PMID： 26792747 PMCID： PMC4794656 DOI： 10.1128/JVI.03375-14

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

22 in total

1. ORF66 protein kinase function is required for T-cell tropism of varicella-zoster virus in vivo.

Authors: Anne Schaap-Nutt; Marvin Sommer; Xibing Che; Leigh Zerboni; Ann M Arvin
Journal: J Virol Date: 2006-09-13 Impact factor: 5.103

2. Vaccine Oka varicella-zoster virus genotypes are monomorphic in single vesicles and polymorphic in respiratory tract secretions.

Authors: Mark A Quinlivan; Anne A Gershon; Richard A Nichols; Philip La Russa; Sharon P Steinberg; Judy Breuer
Journal: J Infect Dis Date: 2006-02-27 Impact factor: 5.226

Review 3. Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases.

Authors: Angela Erazo; Paul R Kinchington
Journal: Curr Top Microbiol Immunol Date: 2010 Impact factor: 4.291

Review 4. A deep profiler's guide to cytometry.

Authors: Sean C Bendall; Garry P Nolan; Mario Roederer; Pratip K Chattopadhyay
Journal: Trends Immunol Date: 2012-04-02 Impact factor: 16.687

5. Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus.

Authors: Nandini Sen; Gourab Mukherjee; Adrish Sen; Sean C Bendall; Phillip Sung; Garry P Nolan; Ann M Arvin
Journal: Cell Rep Date: 2014-07-17 Impact factor: 9.423

Review 6. Molecular mechanisms of varicella zoster virus pathogenesis.

Authors: Leigh Zerboni; Nandini Sen; Stefan L Oliver; Ann M Arvin
Journal: Nat Rev Microbiol Date: 2014-02-10 Impact factor: 60.633

7. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.

Authors: Sean C Bendall; Erin F Simonds; Peng Qiu; El-ad D Amir; Peter O Krutzik; Rachel Finck; Robert V Bruggner; Rachel Melamed; Angelica Trejo; Olga I Ornatsky; Robert S Balderas; Sylvia K Plevritis; Karen Sachs; Dana Pe'er; Scott D Tanner; Garry P Nolan
Journal: Science Date: 2011-05-06 Impact factor: 47.728

Review 8. WHO-EORTC classification for cutaneous lymphomas.

Authors: Rein Willemze; Elaine S Jaffe; Günter Burg; Lorenzo Cerroni; Emilio Berti; Steven H Swerdlow; Elisabeth Ralfkiaer; Sergio Chimenti; José L Diaz-Perez; Lyn M Duncan; Florent Grange; Nancy Lee Harris; Werner Kempf; Helmut Kerl; Michael Kurrer; Robert Knobler; Nicola Pimpinelli; Christian Sander; Marco Santucci; Wolfram Sterry; Maarten H Vermeer; Janine Wechsler; Sean Whittaker; Chris J L M Meijer
Journal: Blood Date: 2005-02-03 Impact factor: 22.113

9. Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infection.

Authors: Xibing Che; Mike Reichelt; Marvin H Sommer; Jaya Rajamani; Leigh Zerboni; Ann M Arvin
Journal: J Virol Date: 2008-04-09 Impact factor: 5.103

10. The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse.

Authors: J F Moffat; L Zerboni; M H Sommer; T C Heineman; J I Cohen; H Kaneshima; A M Arvin
Journal: Proc Natl Acad Sci U S A Date: 1998-09-29 Impact factor: 11.205

7 in total

Review 7. Current Challenges in Vaccinology.

Authors: Richard B Kennedy; Inna G Ovsyannikova; Peter Palese; Gregory A Poland
Journal: Front Immunol Date: 2020-06-25 Impact factor: 7.561

7 in total

Dissecting the Molecular Mechanisms of the Tropism of Varicella-Zoster Virus for Human T Cells.

1. ORF66 protein kinase function is required for T-cell tropism of varicella-zoster virus in vivo.

2. Vaccine Oka varicella-zoster virus genotypes are monomorphic in single vesicles and polymorphic in respiratory tract secretions.

Review 3. Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases.

Review 4. A deep profiler's guide to cytometry.

5. Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus.

Review 6. Molecular mechanisms of varicella zoster virus pathogenesis.

7. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.

Review 8. WHO-EORTC classification for cutaneous lymphomas.

9. Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infection.

10. The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse.

Review 1. Herpes zoster and the search for an effective vaccine.

2. Insights into the pathogenesis of varicella viruses.

3. Varicella-Zoster Virus and the Enteric Nervous System.

4. Varicella zoster virus productively infects human natural killer cells and manipulates phenotype.

Review 5. Manipulation of the Innate Immune Response by Varicella Zoster Virus.

6. Guillain-Barré syndrome following varicella-zoster virus infection.

Review 7. Current Challenges in Vaccinology.