Literature DB >> 26792744

Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus.

Eefje J A Schrauwen1, Mathilde Richard2, David F Burke3, Guus F Rimmelzwaan1, Sander Herfst1, Ron A M Fouchier1.   

Abstract

Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high affinity for α2,6-linked sialic acid receptor and acid and temperature stability. Thus, the hemagglutinin of the A/H7N9 virus may adopt traits associated with airborne transmission.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26792744      PMCID： PMC4794686          DOI： 10.1128/JVI.03052-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

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Journal:  J Infect Dis       Date:  2013-08-29       Impact factor: 5.226

2.  Structural analysis of the hemagglutinin from the recent 2013 H7N9 influenza virus.

Authors:  Hua Yang; Paul J Carney; Jessie C Chang; Julie M Villanueva; James Stevens
Journal:  J Virol       Date:  2013-09-11       Impact factor: 5.103

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Journal:  J Virol       Date:  2013-10-30       Impact factor: 5.103

4.  Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.

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Journal:  Science       Date:  2013-12-06       Impact factor: 47.728

7.  Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virus.

Authors:  Martin Linster; Sander van Boheemen; Miranda de Graaf; Eefje J A Schrauwen; Pascal Lexmond; Benjamin Mänz; Theo M Bestebroer; Jan Baumann; Debby van Riel; Guus F Rimmelzwaan; Albert D M E Osterhaus; Mikhail Matrosovich; Ron A M Fouchier; Sander Herfst
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Journal:  Nature       Date:  2013-07-10       Impact factor: 49.962

9.  Adaptation of novel H7N9 influenza A virus to human receptors.

Authors:  J C F M Dortmans; J Dekkers; I N Ambepitiya Wickramasinghe; M H Verheije; P J M Rottier; F J M van Kuppeveld; E de Vries; C A M de Haan
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10.  Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice.

Authors:  Jessica A Belser; Kortney M Gustin; Melissa B Pearce; Taronna R Maines; Hui Zeng; Claudia Pappas; Xiangjie Sun; Paul J Carney; Julie M Villanueva; James Stevens; Jacqueline M Katz; Terrence M Tumpey
Journal:  Nature       Date:  2013-07-10       Impact factor: 49.962
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  24 in total

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Journal:  Cell Rep       Date:  2017-04-11       Impact factor: 9.423

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Authors:  Xiangjie Sun; Jessica A Belser; Hua Yang; Joanna A Pulit-Penaloza; Claudia Pappas; Nicole Brock; Hui Zeng; Hannah M Creager; James Stevens; Taronna R Maines
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3.  Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

Authors:  Eleonora Macchi; Timothy R Rudd; Rahul Raman; Ram Sasisekharan; Edwin A Yates; Annamaria Naggi; Marco Guerrini; Stefano Elli
Journal:  Biochemistry       Date:  2016-11-23       Impact factor: 3.162

4.  Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.

Authors:  Sander Herfst; Jie Zhang; Mathilde Richard; Ryan McBride; Pascal Lexmond; Theo M Bestebroer; Monique I J Spronken; Dennis de Meulder; Judith M van den Brand; Miruna E Rosu; Stephen R Martin; Steve J Gamblin; Xiaoli Xiong; Wenjie Peng; Rogier Bodewes; Erhard van der Vries; Albert D M E Osterhaus; James C Paulson; John J Skehel; Ron A M Fouchier
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5.  NS1 is the fluid for "flu-transmission".

Authors:  Tokiko Watanabe; Masaki Imai; Yoshihiro Kawaoka
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Review 6.  Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk.

Authors:  Charles J Russell; Meng Hu; Faten A Okda
Journal:  Trends Microbiol       Date:  2018-04-19       Impact factor: 17.079

7.  pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.

Authors:  Thomas Gerlach; Luca Hensen; Tatyana Matrosovich; Janina Bergmann; Michael Winkler; Christin Peteranderl; Hans-Dieter Klenk; Friedemann Weber; Susanne Herold; Stefan Pöhlmann; Mikhail Matrosovich
Journal:  J Virol       Date:  2017-05-12       Impact factor: 5.103

Review 8.  Alternative antiviral approaches to combat influenza A virus.

Authors:  Ka Heng Wong; Sunil K Lal
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Review 9.  Hemagglutinin Stability and Its Impact on Influenza A Virus Infectivity, Pathogenicity, and Transmissibility in Avians, Mice, Swine, Seals, Ferrets, and Humans.

Authors:  Charles J Russell
Journal:  Viruses       Date:  2021-04-24       Impact factor: 5.048

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Authors:  Pengxiang Chang; Joshua E Sealy; Jean-Remy Sadeyen; Sushant Bhat; Deimante Lukosaityte; Yipeng Sun; Munir Iqbal
Journal:  J Virol       Date:  2020-09-15       Impact factor: 5.103
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