| Literature DB >> 26792253 |
Priscila Conrado Guerra Nunes1, Marciano Viana Paes2, Carlos Alberto Basilio de Oliveira3, Ana Carla Gomes Soares4, Ana Maria Bispo de Filippis1, Monique da Rocha Queiroz Lima1, Ada Maria de Barcelos Alves2, Juliana Fernandes Amorim da Silva2, Janice Mery Chicarino de Oliveira Coelho5, Francisco das Chagas de Carvalho Rodrigues5, Rita Maria Ribeiro Nogueira1, Flávia Barreto Dos Santos1.
Abstract
In Brazil, dengue is a public health problem with the occurrence of explosive epidemics. This study reports maternal and fetal deaths due to dengue and which tissues of placenta and umbilical cord were analyzed by molecular methods and immunohistochemistry. The dengue NS3 and NS1 detection revealed the viral presence in different cells from placenta and umbilical cord. In the latter, DENV-2 was detected at a viral titer of 1,02 × 10(4) amounts of viral RNA. It was shown that the DENV markers analyzed here may be an alternative approach for dengue fatal cases investigation, especially involving maternal and fetal death. J. Med. Virol. 88:1448-1452, 2016.Entities:
Keywords: Brazil; NS1; NS3; dengue; maternal and fetal death
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Year: 2016 PMID： 26792253 DOI： 10.1002/jmv.24479
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327