Literature DB >> 26791791

Cascade polycyclizations in natural product synthesis.

R Ardkhean1, D F J Caputo1, S M Morrow1, H Shi1, Y Xiong1, E A Anderson1.   

Abstract

Cascade (domino) reactions have an unparalleled ability to generate molecular complexity from relatively simple starting materials; these transformations are particularly appealing when multiple rings are forged during this process. In this tutorial review, we cover recent highlights in cascade polycyclizations as applied to natural product synthesis, including pericyclic, heteroatom-mediated, cationic, metal-catalyzed, organocatalytic, and radical sequences.

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Year:  2016        PMID: 26791791     DOI: 10.1039/c5cs00105f

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN: 0306-0012            Impact factor:   54.564


  14 in total

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Authors:  Hem Raj Khatri; Nolan Carney; Ryan Rutkoski; Bijay Bhattarai; Pavel Nagorny
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Review 2.  Expanding the medicinal chemistry synthetic toolbox.

Authors:  Jonas Boström; Dean G Brown; Robert J Young; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2018-08-24       Impact factor: 84.694

3.  A metal-free aromative cascade for the synthesis of diverse heterocycles.

Authors:  Steven C Schlitzer; Dhanarajan Arunprasath; Katelyn G Stevens; Indrajeet Sharma
Journal:  Org Chem Front       Date:  2020-01-02       Impact factor: 5.281

Review 4.  Total synthesis of complex terpenoids employing radical cascade processes.

Authors:  Kevin Hung; Xirui Hu; Thomas J Maimone
Journal:  Nat Prod Rep       Date:  2018-02-21       Impact factor: 13.423

Review 5.  Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step.

Authors:  Bastien Delayre; Qian Wang; Jieping Zhu
Journal:  ACS Cent Sci       Date:  2021-04-08       Impact factor: 14.553

6.  Gold(I)-Catalyzed Inter- and Intramolecular Additions of Carbonyl Compounds to Allenenes.

Authors:  Tania Jiménez; Javier Carreras; Julien Ceccon; Antonio M Echavarren
Journal:  Org Lett       Date:  2016-02-26       Impact factor: 6.005

Review 7.  A Case for Bond-Network Analysis in the Synthesis of Bridged Polycyclic Complex Molecules: Hetidine and Hetisine Diterpenoid Alkaloids.

Authors:  Nicolle A Doering; Richmond Sarpong; Reinhard W Hoffmann
Journal:  Angew Chem Int Ed Engl       Date:  2020-04-15       Impact factor: 15.336

8.  Polycyclizations of Ketoesters: Synthesis of Complex Tricycles with up to Five Stereogenic Centers from Available Starting Materials.

Authors:  Martin Kamlar; August Runemark; Ivana Císařová; Henrik Sundén
Journal:  Org Lett       Date:  2020-10-20       Impact factor: 6.005

9.  SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis.

Authors:  Masao Ohashi; Fang Liu; Yang Hai; Mengbin Chen; Man-Cheng Tang; Zhongyue Yang; Michio Sato; Kenji Watanabe; K N Houk; Yi Tang
Journal:  Nature       Date:  2017-09-13       Impact factor: 49.962

10.  Total Synthesis of the Schisandraceae Nortriterpenoid Rubriflordilactone A.

Authors:  Guilhem Chaubet; Shermin S Goh; Mujahid Mohammad; Birgit Gockel; Marie-Caroline A Cordonnier; Hannah Baars; Andrew W Phillips; Edward A Anderson
Journal:  Chemistry       Date:  2017-09-08       Impact factor: 5.236

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