Literature DB >> 26789558

Nrl-Cre transgenic mouse mediates loxP recombination in developing rod photoreceptors.

Diana S Brightman1,2, David Razafsky1, Chloe Potter1, Didier Hodzic1, Shiming Chen1,3.   

Abstract

The developing mouse retina is a tractable model for studying neurogenesis and differentiation. Although transgenic Cre mouse lines exist to mediate conditional genetic manipulations in developing mouse retinas, none of them act specifically in early developing rods. For conditional genetic manipulations of developing retinas, a Nrl-Cre mouse line in which the Nrl promoter drives expression of Cre in rod precursors was created. The results showed that Nrl-Cre expression was specific to the retina where it drives rod-specific recombination with a temporal pattern similar to endogenous Nrl expression during retinal development. This Nrl-Cre transgene does not negatively impact retinal structure and function. Taken together, the data suggested that the Nrl-Cre mouse line was a valuable tool to drive Cre-mediated recombination specifically in developing rods.
© 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  differentiation; neuronal development; retina-specific Cre; transgenic

Mesh：

Substances：

Year:  2016        PMID： 26789558      PMCID： PMC4803539          DOI： 10.1002/dvg.22918

Source DB:  PubMed          Journal:  Genesis        ISSN： 1526-954X            Impact factor:   2.487


  19 in total

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