J Qiu1, Y Zhou2, X Yang2, Y Zhang1, Z Li3, N Yan4, Y Wang4, S Ge4, S Wu5, X Zhao2, W Wang1,4,6. 1. School of Public Health, Ningxia Medical University, Yinchuan, China. 2. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 3. Department of Cardiology, Tangshan People's Hospital, Hebei United University, Tangshan, China. 4. Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China. 5. Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, China. 6. School of Medical Sciences, Edith Cowan University, Perth, WA, Australia.
Abstract
BACKGROUND AND PURPOSE: Routine screening for asymptomatic cranial-carotid stenosis (ACCS) is controversial and recommendation in clinical practice is vague. The ankle-brachial index (ABI) is reported as a predictor for cardiovascular disease. However, there is a scarcity of data about the association between abnormal ABI and ACCS. A population-based cross-sectional study was conducted to explore the relationship between ABI and ACCS. METHODS: A sample of 5440 Chinese adults aged 40-94 years old was recruited from 2010 to 2011. The ABI was measured using a portable Doppler device and ACCS was evaluated by bilateral carotid duplex ultrasound and portable examination devices. A logistic regression model was used to analyse the association between ABI and ACCS after adjusting for potential confounding factors. RESULTS: A low ABI was associated with ACCS [odds ratio (OR) 1.95, 95% confidence interval (CI) 1.42-2.67] after adjusting for potential confounders. When the data were stratified by age and sex, the correlation remained statistically significant in the male (OR 2.32, 95% CI 1.60-3.37) and elderly (OR 3.07, 95% CI 1.97-4.78) subgroups compared to the female (OR 1.26, 95% CI 0.67-2.39) and middle-aged groups (OR 1.27, 95% CI 0.77-2.12), respectively. CONCLUSION: This study demonstrated that low ABI is a significant risk factor for ACCS in male and elderly Chinese adults.
BACKGROUND AND PURPOSE: Routine screening for asymptomatic cranial-carotid stenosis (ACCS) is controversial and recommendation in clinical practice is vague. The ankle-brachial index (ABI) is reported as a predictor for cardiovascular disease. However, there is a scarcity of data about the association between abnormal ABI and ACCS. A population-based cross-sectional study was conducted to explore the relationship between ABI and ACCS. METHODS: A sample of 5440 Chinese adults aged 40-94 years old was recruited from 2010 to 2011. The ABI was measured using a portable Doppler device and ACCS was evaluated by bilateral carotid duplex ultrasound and portable examination devices. A logistic regression model was used to analyse the association between ABI and ACCS after adjusting for potential confounding factors. RESULTS: A low ABI was associated with ACCS [odds ratio (OR) 1.95, 95% confidence interval (CI) 1.42-2.67] after adjusting for potential confounders. When the data were stratified by age and sex, the correlation remained statistically significant in the male (OR 2.32, 95% CI 1.60-3.37) and elderly (OR 3.07, 95% CI 1.97-4.78) subgroups compared to the female (OR 1.26, 95% CI 0.67-2.39) and middle-aged groups (OR 1.27, 95% CI 0.77-2.12), respectively. CONCLUSION: This study demonstrated that low ABI is a significant risk factor for ACCS in male and elderly Chinese adults.
Authors: Michiel H F Poorthuis; Alison Halliday; M Sofia Massa; Paul Sherliker; Rachel Clack; Dylan R Morris; Robert Clarke; Gert J de Borst; Richard Bulbulia; Sarah Lewington Journal: J Am Heart Assoc Date: 2020-04-20 Impact factor: 5.501